LysM蛋白在植物免疫中的作用

The role of LysM protein in plant immunity

溶解素基序(LysM)是在多种蛋白质中普遍存在的结构域.植物LysM蛋白能够感知几丁质及其寡糖等分子配体,从而启动植物对病原菌的免疫反应.在水稻、拟南芥等植物免疫应答过程中,LysM蛋白作为一种重要的模式识别受体,通过不同形式的寡聚化,激活多种类受体胞质激酶及其下游的MAPK(mitogen activated protein kinase)级联反应传递信号.同时,蛋白质可逆磷酸化和蛋白质降解途径可以负调节LysM蛋白介导的防御信号转导.文章综述了植物免疫过程中LysM蛋白介导的信号转导分子机制.

Lysin motif(LysM)is a ubiquitous domain in multiple proteins.LysM-containing proteins in plants have the ability of sensing chitin or its oligosaccharides,thereby initiating plant immune responses to pathogens.During the immune response process in plants such as rice and Arabidopsis,LysM-containing proteins work as an important pattern recognition receptor through diverse forms of oligomerization,and then trigger cytoplasmic receptor-like kinases,and mitogen activated protein kinase(MAPK)cascades for signal transduction.Meanwhile,reversible protein phosphorylation and protein degradation pathway could negatively regulate the LysM-containing proteins-mediated defense signal transduction.This paper reviews the molecular mechanism underlying the LysM-mediated signal transduction implemented during plant immunity.