静电纺丝纳米纤维在牙周再生中的应用

Application of electrospun nanofibers in periodontal regeneration

静电纺丝技术通过高压电场制备纳米纤维,这类材料具有优良的生物相容性、生物降解性;同时具有高孔隙率和高比表面积,可模拟天然细胞外基质的结构,促进细胞增殖和分化;通过负载无机粒子、药物等活性物质可优化材料的生物性能。因此,静电纺丝纳米纤维已广泛应用于骨、软骨、神经、皮肤等组织再生,也是牙周组织再生研究中的热门材料。本文简要阐述了静电纺丝纳米纤维的制备过程,并从基质成分、生物活性和结构方面介绍其在牙周组织再生中的应用,旨在为其进一步研究和开发提供参考。

Nanofibers are prepared by electrospinning technique through a high voltage electric field. These materials have good biocompatibility and biodegradability. Simultaneously, materials with high porosity and high specific surface area can simulate the structure of the natural extracellular matrix and thus promote cell proliferation and differentiation.The biological properties of materials can be optimized by loading inorganic particles, drugs, and other active substances.Therefore, electrospinning nanofibers have been widely used in the regeneration of bone, cartilage, nerve, skin, and other tissues, and are also popular materials in periodontal tissue regeneration. Hence, this review briefly describes the preparation process of electrospun nanofibers, and introduces their application in periodontal tissue regeneration from the aspects of matrix composition, biological activity, and structure, aiming to provide a reference for its further research and development.