胰岛素样生长因子-1在早产儿相关并发症中的研究进展

Progress of insulin-like growth factor-1 in preterm related complications

随着围生医学的进步, 早产儿生存率大幅提升, 但生长迟缓、早产儿脑损伤、早产儿视网膜病变、支气管肺发育不良以及坏死性小肠结肠炎等早产相关并发症的发生率也随之增高。胰岛素样生长因子-1(insulin-like growth factor-1, IGF-1)与IGF-1受体特异性结合, 激活细胞内信号通路, 促进细胞生长、增殖和分化, 抑制细胞凋亡。IGF-1参与心、脑、肺等重要器官的发育, 因此对新生儿的生长发育起重要作用。目前已有一些临床试验发现补充重组IGF-1及其结合蛋白-3对早产儿视网膜病变及支气管肺发育不良可以起到预防及治疗的作用, 为这些难治性早产儿并发症的防治带来希望。该文就IGF-1的功能及其在早产儿相关并发症中的研究进展做一综述。

With the progress of perinatal medicine,the survival rate of premature infants has been greatly improved,but the incidence of preterm related complications has also increased,including growth retardation,premature brain injury,retinopathy of prematurity,bronchopulmonary dysplasia and necrotizing enterocolitis.Insulin-like growth factor-1(IGF-1)specifically binds to IGF-1 receptor to activate intracellular signaling pathways,so that can promote cell growth,proliferation and differentiation,and inhibit apoptosis.IGF-1 is involved in the development of the heart,brain,lung,and other important organs and promotes tissue growth,so it plays an important role in fetal intrauterine development and neonatal extrauterine growth.At present,some clinical trials have found that recombinant IGF-1 and its binding protein-3 can play a role in the prevention and treatment of retinopathy of prematurity and bronchopulmonary dysplasia,bringing hope for the prevention and treatment of these refractory complications of prematurity.In this review,the function of IGF-1 and its role in preterm related complications are reviewed.