综合管控措施干预结直肠癌围术期预防使用抗菌药物的效果评价

Effect evaluation of comprehensive management and control measures in intervening antibacterial drugs use during colorectal cancer perioperative period

目的评价综合管控措施干预结直肠癌围术期预防使用抗菌药物的效果。方法从该院已归档的出院病历中随机抽取干预前(2020年1-6月,采用以行政手段为主的常规管理方式)和干预后(2021年1-6月,采用抗菌药物科学化管理策略指导,运用综合管控措施)各300份结直肠癌患者手术病历,分析比较干预前后围术期抗菌药物预防应用情况。结果干预后结直肠癌围术期药品选择合理率、用药时机合理率和总用药时间合理率分别由干预前81.67%、81.00%和8.33%上升至94.00%、89.00%和25.33%;总用药时间由干预前(7.32±2.99)d缩短至(4.00±2.03)d;抗菌药物使用强度、抗菌药物人均费用、住院时间均明显下降(P<0.05)。结论通过抗菌药物科学化管理策略指导,运用综合管控措施对抗菌药物使用过程实施监控,加强环节管理,可以有效提高结直肠癌围术期抗菌药物使用的合理性。

Objective To evaluate the effect of comprehensive management and control measures for intervening the preventive use of antibacterial drugs in colorectal cancer perioperative period.Methods Each 300 surgical medical records of colorectal cancer patients were randomly extracted from the discharge records before intervention(January to June 2020,adopting the conventional management mode based on administrative means)and after intervention(January to June 2021,adopting scientific management strategy of antibiotics and applying the comprehensive intervention measures)in this hospital,and the perioperative antibacterial drugs use situation was analyzed and compared between before and after intervention.Results The rational rates of drug selection,medication timing and medication time of drugs after intervention in colorectal cancer perioperative period were increased from 81.67%,81.00%and 8.33%before the intervention to 94.00%,89.00%and 25.33%,respectively.The total medication time was shortened from(7.32±2.99)d before intervention to(4.00±2.03)d;the antibiotics use intensity,per capita antimicrobial drugs cost and hospitalization days all were decreased significantly(P<0.05).Conclusion Through the guidance of antibacterial drugs scientific management strategy,applying the comprehensive intervention measures to implement to monitor the antimicrobial use process and strengthen the link management can effectively improve the rationality of the antibacterial drugs use during colorectal cancer perioperative period.