IL-5与INF-γ在腺样体肥大伴分泌性中耳炎中的表达及临床意义

Expression and clinical significance of IL-5 and INF-γ in adenoid hypertrophy complicating secretory otitis media

目的研究白细胞介素-5(IL-5)与γ-干扰素(INF-γ)在腺样体肥大伴分泌性中耳炎中的表达,并且分析其临床意义。方法选取2020年1月至2021年6月该院收治的117例腺样体肥大患儿,按照是否伴分泌性中耳炎分为两组,56例单纯腺样体肥大患儿为对照组,61例腺样体肥大伴分泌性中耳炎患儿为研究组。检测并对比两组患儿血清、腺样体组织、中耳积液中IL-5与INF-γ水平。结果两组血清IL-5、INF-γ水平及IL-5/INF-γ比值无明显差异(P>0.05);研究组腺样体组织IL-5水平及IL-5/INF-γ比值均明显高于对照组(P<0.05),INF-γ水平差异无统计学意义(P>0.05)。研究组腺样体组织IL-5、INF-γ水平均明显高于血清及中耳积液(P<0.05),血清与中耳积液的IL-5、INF-γ水平比较差异无统计学意义(P>0.05)。结论IL-5、INF-γ可能成为腺样体肥大伴分泌性中耳炎患儿临床诊断、治疗及预后评估的重要指标。

Objective To investigate the expression and clinical significance of IL-5 and INF-γin adenoid hypertrophy complicating secretory otitis media.Methods One hundred and seventeen children patients with adenoid hypertrophy admitted to this hospital from January 2020 to June 2021 were selected and divided into the two groups according to whether complicating secretory otitis media.Fifty-six case of simple adenoid hypertrophy served as the control group and 61 cases of adenoid hypertrophy complicating secretory otitis media served as the study group.The levels of IL-5 and INF-γin serum,adenoids tissue and middle ear fluid were detected and compared between the two groups.Results The serum IL-5,INF-γlevels and IL-5/INF-γratio had no significant difference between the two groups(P>0.05);while the IL-5 levels and IL-5/INF-γratio in the adenoid tissue of the study group were significantly higher than those of the control group(P<0.05),the INF-γlevel had no statistically significant difference between the two groups(P>0.05);the IL-5 and INF-γlevels in the adenoids tissue of the study group were significantly higher than those in serum and middle ear effusion(P<0.05);the IL-5 and INF-γlevels had no statistical difference between serum and middle ear effusion(P>0.05).Conclusion The IL-5 and INF-γlevels may become the important indicators for the clinical diagnosis,treatment and prognosis evaluation of the children patients with adenoid hypertrophy complicating secretory otitis media.