牙周病促进炎症性肠病机制的研究进展

Research progress on mechanisms of periodontal diseases promoting inflammatory bowel diseases

牙周病与炎症性肠病(IBD)的相互促进关系已得到多项流行病学研究证实。牙龈卟啉单胞菌(P.gingivalis)是一种革兰阴性专性厌氧菌,被认为是牙周病的重要致病菌之一。近年来的研究表明,牙周病与IBD之间的联系可能是由P.gingivalis介导。该文就牙周病与IBD之间的相互促进关系及P.gingivalis作为IBD与牙周病关联核心的相关证据进行归纳,并主要从P.gingivalis的黏附与定植、传播,P.gingivalis对炎症通路的调控作用,肠道细菌多样性的影响,以及免疫功能的影响4个方面对P.gingivalis促进IBD发展的作用机制研究进展做一综述。

The mutual promotion relationship between periodontal disease and inflammatory bowel disease(IBD)has been demonstrated in many epidemiological studies.Porphyromonas gingivalis(P.gingivalis),a Gram-negative obligate anaerobe bacterium,has been proved to be one of the most important pathogens of periodontal disease.The recent studies have shown that the relationship between periodontal disease and IBD may be mediated by P.gingivalis.This paper summarizes the mutual promotion correlation between periodontal disease and IBD and the related evidences of P.gingivalis as the core of the association between IBD and periodontal disease are concluded.The research progress of the mechanism of P.gingivalis promoting the development of IBD is reviewed mainly from four aspects of the adhesion,colonization and transmission of P.gingivalis,the regulation effect of P.gingivalis on inflammatory pathways,the influence of intestinal bacterial diversity,and the influence on immune function.