中医禁食疗法对代谢综合征血浆致动脉粥样硬化指数、Framingham风险评分的影响

Effects of traditional Chinese medicine fasting therapy on atherogenic index of plasma and Framingham risk score of metabolic syndrome

目的观察中医禁食疗法对代谢综合征(metabolic syndrome,MS)患者血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)、Framingham风险评分(Framingham risk score,FRS)的干预作用。方法选取2021年8月至2022年5月就诊于温州市中医院的MS患者90例,根据随机数字表法将其分为禁食组和对照组,每组各45例,同期选取90例健康体检者纳入正常组。对照组患者予正常饮食及运动处方干预,禁食组患者予中医禁食疗法干预,两组患者均干预10d。比较正常组体检时与禁食组、对照组干预前后体质量指数(body mass index,BMI)、血压、血脂、血糖指标、AIP和FRS,分析禁食组、对照组干预疗效,应用Pearson相关性分析探讨MS患者AIP、FRS与临床指标的关系。结果干预前后,禁食组、对照组患者的BMI、收缩压、舒张压、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、空腹血糖(fasting plasma glucose,FPG)、AIP、FRS均显著高于正常组,高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)水平显著低于正常组(P<0.05);干预后,禁食组患者的BMI、收缩压、舒张压、LDL-C、TG、TC、FPG、AIP、FRS均显著低于本组干预前和对照组(P<0.05),HDL-C水平显著高于本组干预前和对照组(P<0.05)。禁食组患者干预后的总有效率显著高于对照组(P<0.05)。MS患者的AIP与BMI、TG水平呈正相关,与HDL-C水平呈负相关(P<0.05),FRS与BMI、收缩压、舒张压、LDL-C、TC水平呈正相关,与HDL-C水平呈负相关(P<0.05)。结论MS患者的AIP、FRS显著增高,且与BMI、血脂等指标有关,应用中医禁食疗法可显著降低AIP、FRS,改善临床指标及疗效,有利于降低心血管疾病风险。

Objective To observe the intervention effect of traditional Chinese medicine fasting therapy on atherogenic index of plasma(AIP)and Framingham risk score(FRS)in patients with metabolic syndrome(MS).Methods A total of 90 patients with MS who visited Wenzhou Hospital of Traditional Chinese Medicine from August 2021 to May 2022 were selected and divided into fasting group and control group according to the random number table method,with 45 cases in each group,and 90 healthy subjects were selected as normal group during the same period.The control group was given normal diet and exercise prescription intervention,and the fasting group was given traditional Chinese medicine fasting therapy intervention.Both groups were intervened for 10 days.The body mass index(BMI),blood pressure,blood lipids,blood glucose indexes,AIP,FRS were compared.The intervention efficacy of fasting group and control group was analyzed.Pearson correlation analysis was used to investigate the relationship between AIP,FRS and clinical indicators in MS patients.Results Before and after intervention,BMI,systolic blood pressure,diastolic blood pressure,low density lipoprotein-cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC),fasting plasma glucose(FPG),AIP and FRS in fasting group and control group were significantly higher than those in normal group,high density lipoprotein-cholesterol(HDL-C)levels were significantly lower than those in normal group(P<0.05).After intervention,BMI,systolic blood pressure,diastolic blood pressure,LDL-C,TG,TC,FPG,AIP and FRS of fasting group were significantly lower than those before intervention and control group(P<0.05),and HDL-C levels were significantly higher than those before intervention and control group(P<0.05).The total effective rate after intervention in fasting group was significantly higher than that in control group(P<0.05).AIP in MS patients was positively correlated with BMI and TG levels,and negatively correlated with HDL-C levels(P<0.05).FRS was positively correlated with BMI,systolic blood pressure,diastolic blood pressure,LDL-C and TC levels,and negatively correlated with HDL-C levels(P<0.05).Conclusion The AIP and FRS of MS patients are significantly increased,and are related to BMI,blood lipids and other indicators.The application of traditional Chinese medicine fasting therapy intervention can significantly reduce the AIP and FRS,improve clinical indicators and curative effects,and reduce the risk of cardiovascular disease.