地屈孕酮联合醋酸亮丙瑞林微球对子宫内膜异位症合并内膜增生不孕术后患者的干预效果

Intervention effect of dydrogesterone combined with leuprolide acetate microspheres on postoperative infertility patients with endometriosis and endometrial hyperplasia

目的观察地屈孕酮联合醋酸亮丙瑞林微球对子宫内膜异位症合并内膜增生不孕术后患者的干预效果。方法选择2019年6月至2020年6月收治的94例子宫内膜异位症合并内膜增生不孕患者为研究对象,遵循随机、平均原则将其分为对照组和观察组,各47例。两组患者均实施宫腔镜手术治疗,对照组术后采用醋酸亮丙瑞林微球治疗,观察组术后采用醋酸亮丙瑞林微球联合地屈孕酮治疗。比较两组的干预效果。结果观察组的临床病情控制总有效率高于对照组(P<0.05)。治疗6个月后,观察组的促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及血管内皮生长因子(VEGF)水平均低于对照组和治疗前(P<0.05)。随访1年,观察组的妊娠率高于对照组(P<0.05)。结论将地屈孕酮联合醋酸亮丙瑞林微球应用于子宫内膜异位症合并内膜增生不孕术后患者中,有利于提升临床效果、改善性激素水平及减轻炎症反应。

Objective To observe the intervention effect of dydrogesterone combined with leuprolide acetate microspheres on postoperative infertility patients with endometriosis and endometrial hyperplasia.Methods Ninety-four infertility patients with endometriosis and endometrial hyperplasia admitted from June 2019 to June 2020 were selected as subjects.The patients were divided into control group and observation group according to the random and average principle,with 47cases in each group.Both groups were treated with hysteroscopic surgery.The control group was treated with leuprorelin acetate microspheres after operation,and the observation group was treated with leuprorelin acetate microspheres combined with dydrogesterone after operation.The intervention effects of the two groups were compared.Results The total effective rate of clinical disease control in the observation group was higher than that in the control group(P<0.05).After 6 months of treatment,the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and vascular endothelial growth factor(VEGF)in the observation group were lower than those in the control group and before treatment(P<0.05).After 1 year of follow-up,the pregnancy rate of the observation group was higher than that of the control group(P<0.05).Conclusion The application of dydrogesterone combined with leuprorelin acetate microspheres in postoperative infertility patients with endometriosis and endometrial hyperplasia is beneficial to enhance the clinical effect,improve the levels of sex hormones and reduce the inflammatory response.