铁死亡机制在视网膜色素上皮细胞损伤相关眼病中的研究进展

Research progress on the mechanism of ferroptosis in ocular disease associated with retinal pigment epithelial cell injury

铁死亡(ferroptosis)是一种新发现的以脂质过氧化和铁积累为特征的程序性细胞死亡。近年来,随着铁死亡概念的提出和其机制研究的不断深入,视网膜色素上皮细胞(retinal pigment epithelium cells, RPECs)功能下降相关眼病如年龄相关性黄斑变性(age-related macular degeneration, AMD)、视网膜色素变性(retinitis pigmentosa, RP)和糖尿病视网膜病变(diabetic retinopathy, DR)等疾病的发病机制的探索也取得了重大突破。本文将对铁死亡的基本概念、RPECs铁死亡的主要机制及调控铁死亡对RPECs相关眼病发生发展的作用研究进行综述,希望为RPECs相关眼病发病机制的研究提供参考。

·Ferroptosis is a newly identified programmed cell death characterized by lipid peroxidation and iron accumulation. In recent years, with the proposal of the concept of ferroptosis as well as the deepening of its mechanism research, great breakthroughs have been made in the exploration of the pathogenesis of ocular diseases related to the function decline of retinal pigment epithelium cells(RPECs), such as age-related macular degeneration(AMD), retinitis pigmentosa(RP) and diabetic retinopathy(DR). This article reviews the basic concept of ferroptosis, the main mechanism of ferroptosis in RPECs and the role of ferroptosis regulation in the development of RPECs-related ocular diseases, hoping to provide references for the study of the pathogenesis of RPECs-related ocular diseases.