共价有机框架材料在药物递送中的应用进展

Application of Covalent Organic Framework Materials in Drug Delivery

共价有机框架(Covalent organic frameworks,COFs)是一类通过共价键连接形成的新兴多孔结晶有机聚合物,具有比表面积大、孔隙高度可调及易于化学修饰等特点,是近年来多孔材料领域的研究热点。载药量高、细胞毒性低、生物相容性良好和药物释放能力高效等特点为COFs材料在药物递送领域提供了良好的应用潜力。简要总结了近年来药物递送载体的研究进展,介绍了COFs及其复合材料的合成方法及表征,列举了COFs作为几种模型药物(如阿霉素、5-氟尿嘧啶等)的载体在药物递送中的应用,提出了COFs材料在药物递送领域中的优势,最后对目前COFs材料在药物递送领域所面临的挑战和未来发展的机遇进行了总结和展望。

Covalent organic frameworks(COFs)are a new class of porous crystalline organic polymers formed by covalent bonding.They have the characteristics of a large specific surface area,adjustable pore height,and easy chemical modification,which are the research hotspots in the porous material field.The characteristics of high drug loading,low cytotoxicity,good biocompatibility,and high drug release ability provide COFs with good application potential in the field of drug delivery.In recent years,the research progress of drug delivery carriers was briefly summarized,the synthesis methods and characterization of COFs and their composites were introduced,and COFs were listed as carriers of several model drugs(such as doxorubicin,5-fluorouracil,etc).The application of COFs materials in the field of drug delivery was proposed,and finally the challenges and future development opportunities were summarized and prospected.