Pathogenesis of anti-melanoma differentiation-associated gene-5(MDA5)dermatomyositis

Dermatomyositis(DM)is an idiopathic inflammatory myopathy,with typical cutaneous manifestations and muscle lesions,usually involving multiple organs.Patients with antimelanoma differentiation-associated gene-5(MDA5)DM usually present with clinical amyopathic DM(CADM),which is characterized by a series of unique skin and systemic manifestations,including skin ulcer and interstitial lung disease(ILD).Among them,ILD is the most common complication of anti-MDA5 DM,and in some cases,it can develop into rapidly progressive ILD(RP-ILD).^([1,2])