铁死亡在脓毒症中有关通路的研究进展

Research progress of ferroptosis related pathways in sepsis

脓毒症是由细菌等病原微生物引起的宿主反应失调所致器官功能障碍并伴有高病死率的一种疾病,前期以炎症反应为主,后期则主要表现为免疫抑制,仅用重症感染和免疫抑制来解释脓毒症导致的不良预后已略显苍白;从全球脓毒症绝对病死率的角度看,关于脓毒症的战役并未取得全面胜利;"铁死亡"自2012年由Dixion等正式提出至今已有10年,研究范畴从最初的肿瘤相关疾病,到神经系统疾病及心血管系统疾病,热度始终不减,并取得了一定的进展。目前,在脓毒症背景下,发现铁死亡在各器官功能障碍中扮演着越来越重要的角色,对疾病的治疗及预后亦有着重要影响。现对主要的几种铁死亡相关通路及干预措施进行概述,以便更全面地了解脓毒症的发病机制,寻求新的治疗靶点,优化诊治策略,提高患者生存率和生存质量以及改善临床预后。

Sepsis is a disease caused by pathogenic microorganisms such as bacteria,which is characterized by host response disorder,organ dysfunction and high mortality.In early stage,it is mainly inflammatory reaction,howeverin late stage,it is mainly immunosuppression.It is a little pale to explain the poorprognosis caused by sepsis only by severe infection and immunosuppression.From the perspective of the absolute mortality of sepsis over the world,the battle against sepsis has not won a comprehensive victory.It has been 10 years since"ferroptosis"was formally proposed by Dixionet al.in 2012.The research areahas never decreased from the initial tumor related diseases to nervous system diseases and cardiovascular system diseases,and has made some progress.At present,in the context of sepsis,it is found that ferroptosis plays an increasingly important role in organ dysfunction,and also has an important impact on the treatment and prognosis of the disease.This article summarizes the related pathways and interventions of several major ferroptosis at present,in order to have a more comprehensive understanding of the pathogenesis of sepsis,seek new treatment targets,optimize diagnosis and treatment strategies,and improve survival rate,quality of life and clinical prognosis.