基于数据挖掘的国医大师段富津治疗肝硬化用药规律研究

Study on the medication rule of TCM master Duan Fujin in the treatment of liver cirrhosis based on data mining

目的基于数据挖掘方法研究国医大师段富津治疗肝硬化的用药规律。方法收集并整理段富津教授肝硬化患者病历,进行常用药物频次统计和关联规则分析,对高频药物进行系统聚类分析并得到新处方。结果共收集段富津教授处方162首,涉及中药115味,药物药性以寒、温、平为主,药味以苦、辛、甘居多,归经多归肝、脾、心、胃经。使用频次较高的药物为柴胡、郁金、茯苓、鳖甲、炙甘草等;高频药物组合为柴胡-郁金、柴胡-茯苓、郁金-茯苓、郁金-鳖甲、柴胡-鳖甲、郁金-茯苓-柴胡、郁金-鳖甲-柴胡、郁金-炙甘草-柴胡、柴胡-川芎-郁金、郁金-鳖甲-茯苓、柴胡-鳖甲-茯苓。聚类分析得出新处方2个,第1类为健脾祛湿、理气化痰方,由半夏、陈皮、炙甘草、砂仁、枳壳、茯苓、白术、人参、厚朴、大腹皮、炒麦芽、山楂组成;第2类为行气活血、软坚散结方,由当归、黄芪、鳖甲、牡蛎、郁金、延胡索、桃仁、川楝子、赤芍、丹参、莪术、牡丹皮、白花蛇舌草组成。结论段富津教授治疗肝硬化以疏肝行气、软坚散结为主,重视活血化瘀、健脾祛湿。

Objective To analyze the medication rule of Duan Fujin in the treatment of liver cirrhosis based on data mining method.Methods By searching for and collecting the medical records of patients with liver cirrhosis treated by Traditional Chinese Medicine master Duan Fujin,counting the frequently used Chinese medicines and analyzing their association rules to carry out the system cluster analysis of frequently showed medicines,and to gain new prescriptions.Results A total of 162 prescriptions of Professor Duan Fujin were collected,including 115 Chinese medicines,most of which are bitter and pungent in terms of taste.The medicines which are frequently used are Bupleuri Radix,Curcumae Radix,Poria,Trionycis Carapax,Glycyrrhizae Radix;the medicine pairs which are frequently appeared are Bupleuri Radix-Curcumae Radix,Bupleuri Radix-Poria,Curcumae Radix-Poria,Curcumae Radix-Trionycis Carapax,Bupleuri Radix-Trionycis Carapax,Curcumae Radix-Poria-Bupleuri Radix,Curcumae Radix-Trionycis Carapax-Bupleuri Radix,Curcumae Radix-Glycyrrhizae Radix-Bupleuri Radix,Bupleuri Radix-Chuanxiong Rhizoma-Curcumae Radix,Curcumae Radix-Trionycis Carapax-Poria,Bupleuri Radix-Trionycis Carapax-Poria.Cluster analysis shows that there are two new prescriptions:the first prescription plays the role of invigorating spleen and removing dampness,regulating qi and resolving phlegm,which is composed of Pinelliae Rhizoma,Citri Reticulatae Pericarpium,Glycyrrhizae Radix,Amomi Fructus,Aurantii Fructus,Poria,Atractylodis Macrocephalae Rhizoma,Ginseng Radix,Magnoliae Officinalis Cortex,Arecae Pericarpium,Hordei Fructus Germinatus,Crataegi Fructus;the second prescription plays the role of invigorating Qi and activating blood circulation,Ruanjian Sanjie,which is composed of Angelicae Sinensis Radix,Astragali Radix,Trionycis Carapax,Ostreae Concha,Curcumae Radix,Corydalis Rhizoma,Persicae Semen,Toosendan Fructus,Paeoniae Radix Rubra,Salviae Miltiorrhizae Radix,Curcumae Rhizoma,Moutan Cortex,Hedyotis diffusa Willd.Conclusion The treatment of liver cirrhosis by Duan Fujin's mainly focuse on soothing and promoting the liver qi,softening the hard and disperse the knot,promoting blood circulation and removing blood stasis,strengthening the spleen qi and removing dampness.