基于CiteSpace对治疗血管性痴呆的可视化分析

Visualization of research in treatment of vascular dementia by CiteSpace

我国血管性痴呆患者数量庞大,而定期回顾治疗血管性痴呆相关领域的研究重点,对促进治疗血管性痴呆发展十分必要。该研究检索了中国知网(CNKI)与Web of Science数据库自2012年1月1日至2021年12月31日收录的研究治疗血管性痴呆的国内外文献,使用CiteSpace 5.7.R2软件对国家、机构、作者、关键词及期刊等内容进行可视化展示,并对治疗血管性痴呆研究的现状及发展趋势进行分析,以发现研究重点、演化路径及发展趋势,为今后研究提供辅助与参考。经过筛选最终纳入中文文献2 579篇,英文文献453篇。结果显示,年度发文量呈现波动上升趋势;发表相关文献最多的国家是中国,而中心性最大的是英国;发表中文和英文文献量最多的作者是胡跃强和LIU Cun-zhi;发表中文和英文文献量最多的机构是广西中医药大学和首都医科大学;中心性最高与被引频次最高的英文杂志是《Anal Biochem》《Stroke》;中文文献关键词分析显示治疗血管性痴呆研究集中在治疗后患者活动能力的观察,研究较多的治疗方法是西药、中药与针刺治疗,基础研究的重点是氧化应激、血管新生和细胞凋亡等;英文文献关键词分析显示治疗血管性痴呆的研究重点集中在改善血管性痴呆患者的记忆功能,基础研究的重点是细胞自噬、神经再生和氧化应激等。该研究总结发现中西医结合治疗血管性痴呆为未来研究的热点趋势。

In light of the tremendous number of patients with vascular dementia in China, it is of great significance for the treatment of this disease to summarize related research focuses. In this study, articles on the treatment of vascular dementia, which were included in CNKI and Web of Science from January 1, 2012 to December 31, 2021, were analyzed. Specifically, CiteSpace 5.7.R2 was employed to visualize nationalities of authors, author affiliations, authors, keywords, and journals, and dissect the status quo and trend of research on the treatment of this disease. On this basis, the research focuses and evolution were elucidated. The findings are expected to serve as reference for the future research. Finally, 2 579 Chinese articles and 453 English articles were included. The annual number of published articles showed an upward trend. Authors from China published most papers and England had the highest centrality value. HU Yue-qiang and LIU Cun-zhi respectively published the most Chinese and English articles. Guangxi University of Chinese Medicine and Capital Medical University respectively topped the author affiliations in the number of published Chinese and English articles. Among the English journals, Anal Biochem and Stroke separately boasted the highest centrality value and the highest cited frequency. The analysis of keywords in the Chinese articles suggested that most studies on the treatment of vascular dementia focused on the observation of patients′ mobility after treatment. Moreover, as for the therapeutic method, western medicine, as well as the Chinese medicine and acupuncture frequently attracted the attention of scholars. Basic research highlighted the oxidative stress, angiogenesis, and apoptosis. According to the analysis result of keywords in English articles on treatment of vascular dementia, the focus was the improvement of the memory function of patients with vascular dementia. As to the therapeutic method, drug therapy was frequently studied compared with other methods. The basic research focused on autophagy, nerve regeneration, and oxidative stress. This study concludes that the future research trend might be the combination of Chinese and western medicine in the treatment of vascular dementia.