摘要
线粒体是一种高度动态的细胞器,其分裂与融合的协调循环被称为“线粒体动力学”。线粒体动力学对于细胞代谢调控、免疫调控、氧化还原稳态及钙稳态维持等生物反应至关重要。细菌侵袭细胞后,通过调控宿主线粒体动力学以促进感染和自身增殖。现对线粒体动力学在细菌感染性疾病中的机制、作用及功能的研究进展作一概述。
Mitochondria are highly dynamic organelles whose coordinated cycles of fission and fusion are known as "mitochondrial dynamics". Mitochondrial dynamics are critical for biological responses such as cellular metabolism, immune regulation, redox homeostasis, and calcium homeostasis maintenance. After bacteria invade cells, they promote infection and self-proliferation by regulating host mitochondrial dynamics. This article reviews the mechanism and function of mitochondrial dynamics in bacterial infection.
作者
李威威(综述)
丁楠(审校)
吴移谋(审校)
LI Wei-wei;DING Nan;WU Yi-mou(Institute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province,University of South China,Hengyang 421000,Hunan Province,China)
出处
《微生物学免疫学进展》
CAS
2022年第5期60-65,共6页
Progress In Microbiology and Immunology
基金
国家自然科学基金(31872643)
湖南省教育厅科学研究项目(21B0404)。
关键词
线粒体动力学
细菌感染
融合
裂变
Mitochondrial dynamics
Bacterial infection
Fusion
Fission
