摘要
多发性骨髓瘤(MM)是一种多见于老年人的血液恶性肿瘤,多系统多脏器受累的疾病特征和衰老、衰弱的交互作用进一步增加治疗难度。衰弱与老年MM患者治疗的耐受性及不良预后有关,基于衰弱评估制定个体化治疗方案以降低治疗相关毒性和治疗中断率,可以改善老年MM患者的生存率。本文就MM特异性衰弱评估体系的建立、临床应用、存在的问题和未来优化的方向进行综述。
Multiple myeloma(MM)is a common hematological malignancy of the elderly.It is characterized by the involvement of multiple organs and its treatment becomes more difficult when aging and frailty exert their influence.In elderly MM patients,frailty is associated with poor tolerance to treatment and poor outcomes.Individualized therapy based on frailty assessment can minimize treatment-related adverse effects and reduce the rate of treatment interruptions,thereby improving the survival in elderly patients.In this review,we aim to provide an overview of the frailty assessment systems for MM patients.We also discuss their clinical applications,issues to be addressed,and future directions for optimizing MM-specific frailty assessment to guide MM treatment in frail elderly patients.
作者
梁璐
薛华
靳凤艳
Liang Lu;Xue Hua;Jin Fengyan(Department of Emergency,the Affiliated Hospital of Hebei University,Baoding 071000,China;Department of Hematology,the Affiliated Hospital of Hebei University,Baoding 071000,China;Department of Hematology,the First Hospital of Jilin University,Changchun 130021,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2022年第12期1525-1529,共5页
Chinese Journal of Geriatrics
基金
国家自然科学基金(81670190)
吉林省中青年科技创新创业卓越人才(团队)项目(创新类)(20210509010RQ)
吉林大学"学科交叉融合创新"项目(2021)
河北省财政厅卫健委老年病防治项目(2020)。
关键词
多发性骨髓瘤
衰弱评估
个体化治疗
Multiple myeloma
Frailty assessment
Individualized treatment
