Cbf-β is required for the development, differentiation, and function of murine mucosal-associated invariant T cells

Mucosal-associated invariant T(MAIT)cells are an evolutionarily conserved subset of T cells that respond to microbial threats via semi-invariant T cell receptor(TCR)-mediated recognition of microbial riboflavin-derivative antigens presented by MHC class I-related(MR1)molecules[1].MAIT cells mediate functions that link innate and acquired immunity in a broad spectrum of diseases,including infection,cancer,allergy,and autoimmunity[2].MAIT cells are abundant in human nonmucosal tissues,where they account for up to 10%of blood T cells and 45%of liver T cells,but are much less abundant in mice[3].