摘要
Sepsis is an overwhelming host reaction to infection that results in high morbidity and mortality.The term sepsis or septicemia originated in 1914,and the definition of sepsis has evolved over time due to the complications of the disease.Systemic inflammatory response syndrome(SIRS)and infection are characteristics of sepsis;however,in the absence of infection,SIRS does not lead to sepsis,and not all cases of sepsis manifest symptoms of systemic inflammation,especially in elderly individuals.
基金
This work was supported by the National Natural Science Foundation of China(81788101 and 81630042 to J.H.
31801158 to Y.Z.)
the National Key R&D Program(2020YFA0803500 to J.H.)
the 111 Project(B12001 to J.H.)
the CAMS Innovation Fund for Medical Science(CIFMS)(2019-I2M-5-062 to J.H.).
