年龄与原发性青光眼发病因素相关性的研究进展

The study of the correlation between age and the pathogenic factors of primary glaucoma:a review

年龄是原发性青光眼重要的危险因素。目前原发性青光眼的具体发生机制尚未阐明,其中眼球解剖学因素、房水动力学因素、眼球生物力学因素和神经代谢因素随年龄改变,从不同层面促成了原发性青光眼的发生和发展。本文汇总国内外有关年龄与原发性青光眼关联的最新研究结果,针对上述4个原发性青光眼的发病因素进行综合分析,以期为临床深入探讨原发性青光眼发病机制,提高原发性青光眼临床诊疗和研究水平提供参考。

Age is an important risk factor for primary glaucoma.While the specific mechanism of primary glaucoma remained unclear,the change of ocular anatomy,the disturbance of aqueous humor balance,the change of ocular biomechanics and the disorder of neurometabolism contribute to the occurrence and development of primary glaucoma.This paper reviewes the latest studies on the correlation between age and the risk factors of glaucoma in the above four aspects,so as to provide some references for the in-depth discussion of the pathophysiology of primary glaucoma,and advancement on diagnosis,treatment and research of primary glaucoma.