组胺受体拮抗剂在新型冠状病毒肺炎治疗中的应用及作用机制研究进展

Application and mechanism of histamine receptor antagonists in treatment of coronavirus disease 2019:research progress

新型冠状病毒肺炎(COVID-19)已造成全球大流行,迫切需要找到控制感染和改善症状的方法。同源建模研究及临床分析均提示组胺受体拮抗剂对治疗COVID-19有广阔前景。本文介绍了组胺H1受体拮抗剂联合阿奇霉素,H2受体拮抗剂法莫替丁单独或联合阿司匹林,以及H1与H2受体拮抗剂联合应用治疗COVID-19的研究进展。本文还介绍了组胺受体拮抗剂在COVID-19治疗中可能的作用机制,并对组胺受体拮抗剂在COVID-19治疗中的应用前景进行展望。

The coronavirus disease 2019(COVID-19)has become a global pandemic.It is urgent to find treatments to control the infection and improve symptoms.Homologous modeling and clinical analyses suggest that histamine receptor antagonists have broad prospects in the treatment of COVID-19.This article introduces the research progress of histamine H1 receptor antagonist combined with azithromycin,histamine H2 receptor antagonist famotidine alone or combined with aspirin,and histamine H1 and H2 receptor antagonists used in combination in the treatment of COVID-19.Finally,the possible mechanism of histamine receptor antagonists in the treatment of COVID-19 was introduced and the application prospect of histamine receptor antagonists in the treatment of COVID-19 was analyzed.