皮肤镜观察中药治疗寻常型银屑病的效果及疗效分析

Efficacy and Analysis of Traditional Chinese Medicine in the Treatment of Psoriasis Vulgaris Observed by Dermoscopy

目的以寻常型银屑病治疗后皮肤镜下血管变化,评估银屑病中药治疗疗效。方法选取寻常型银屑病患者40例。其中,治疗组20例,对照组20例。治疗组病例内服清热解毒汤联合维A酸哈西奈德乳膏外用,4周为1个疗程。对照组病例外用维A酸哈西奈德乳膏,4周为1个疗程。分别于治疗后第0、1、2、3、4周于同1皮损处观察皮肤镜下血管变化,并同时记录该皮损微观银屑病皮损面积和严重程度指数(mPASI)评分,比较2组治疗后指标变化。结果治疗组患者的治疗效果优于对照组患者;2组治疗后局部皮损mPASI评分和血管球直径均下降,且治疗组患者治疗后mPASI评分下降值和血管球直径缩小值比对照组更明显,差异有统计学意义。结论皮肤镜下血管指标可作为银屑病中药治疗疗效的客观评估指标。

Objective In order to evaluate the efficacy of traditional Chinese medicine(TCM)on psoriasis vulgaris according to the dermoscopic vascular changes after treatment.Methods This study included 40 patients with psoriasis vulgaris,20 cases in the treatment group and 20 cases in the control group.Patients in the treatment group were given Qingre Jiedu decoction combined with Hassinide retinoate cream for external use with a course of four weeks.Observed the vascular changes of the same lesions under dermoscopy at 0,1,2,3 and 4 weeks were observed,and its mPASI score was recorded.The changes of indexes between the two groups were compared after treatment.Results The efficacy of the treatment group was better than that of the control group.After treatment,microcosmic psoriasis area and severity index(mPASI)score and globule diameter of the skin lesions decreased in both groups,and the decreasing value in the treatment group was more obvious than that in the control group,which was statistically significant.Conclusion Dermatoscopic vascular index can be used as an objective index to evaluate the efficacy of TCM for psoriasis.