肠道菌群-胆汁酸在腹泻型肠易激综合征发病中的作用

The role of gut microbiota-bile acids in the pathogenesis of irritable bowel syndrome-diarrhea

肠易激综合征(irritable bowel syndrome,IBS)是最常见的功能性胃肠道疾病之一。由于其病程长、易反复、难治愈等特点,对患者的生活质量造成了严重的影响,同时给社会医疗带来了沉重的负担。其中腹泻型IBS(IBS-diarrhea,IBS-D)是IBS中最常见也是危害最大的亚型,其病因和发病机制目前尚不十分明确。现有的研究表明其发病可能与肠黏膜低度炎症、结肠胆汁酸增加、肠道菌群失调、胃肠运动障碍、脑-肠轴功能紊乱等因素有关。本文就肠道菌群、胆汁酸以及法尼醇X受体在IBS-D发病中可能起到的作用作一概述,以期为明确IBS-D的发病机制提供参考依据。

Irritable bowel syndrome(IBS)is one of the most common functional gastrointestinal disorders.Because of its long course,recurrence and difficulty in cure,it has a serious impact on the quality of life of patients and brings a heavy burden to social care.The IBS-diarrhea(IBS-D)type is the most common and harmful subtype of IBS.According to existing studies,its pathogenesis may be related to low inflammation of intestinal mucosa,increased colonic bile acids,dysbiosis of gut microbiota,gastrointestinal motility disorders,and brain-gut axis dysfunction,but its etiology and pathogenesis are not yet clear.In this paper,we briefly reviewed the possible roles of gut microbiota,bile acids,and Farnesoid X receptor in the pathogenesis of IBS-D,with the aim of providing a reference for clarifying the pathogenesis of IBS-D.