489例梅毒血清学阳性住院患者的回顾性分析

Retrospective analysis of 489 serologically positive inpatients with syphilis

目的了解住院患者梅毒的感染情况及临床特征,为梅毒的临床防治提供依据。方法回顾性分析我院2018年1月至2020年12月住院期间梅毒血清学阳性患者的临床特征、实验室检查情况。结果筛查108776例住院患者,共检出489例梅毒阳性,其中男273例,女216例;61~80岁人群段阳性率最高。梅毒血清学阳性率靠前的3个科室为神经内科(1.17%)、骨科(0.76%)、妇产科(0.61%)。血清学阳性患者中隐性梅毒占80.16%,血清固定占7.98%,生物学假阳性占5.32%,6.54%不能明确分类。结论梅毒血清学阳性在住院患者中广泛分布,其中老年梅毒、孕期梅毒值得临床重视。临床中出现梅毒血清学阳性,还需警惕隐性梅毒、血清固定、生物学假阳性的情况,实验室检查、病史及随访对三者的区分很重要。

Objective To investigate the infection status and clinical characteristics of patients with syphilis,in order to provide a basis for clinical prevention and treatment of syphilis.Methods Clinical characteristics and laboratory inspection of syphilis inpatients in our hospital from January 2018 to December 2020 were retrospectively analyzed.Results 108776 inpatients were tested in the study,the positive results of male inpatients was 273 and that of female was 216.The positive rate of syphilis was the highest in the age group from 61 to 80 years old.The higher positive rate of departments were neurology,orthopedics,gynaecology and obstetrics.The rate was 1.17%,0.76%,0.61%,respectively.Among the positive of serology of syphilis patients,80.16%were latent syphilis,7.98%were serum fixed,5.32%were biological false positive,6.54%were difficult to distinguish.Conclusion We should take care of the aged and pregnant woman.Latent syphilis,serum fixed and biological false positive should be considered when positive of serology of syphilis is found,medical history and follow-up is important.