丁苯酞氯化钠联合奥扎格雷钠对急性脑梗死患者预后的影响

Effect of Butylphthalide Sodium Chloride Combined with Ozagrel Sodium on Prognosis of Patients with Acute Cerebral Infarction

目的探讨丁苯酞氯化钠联合奥扎格雷钠治疗急性脑梗死患者的临床效果。方法选取2018年3月至2020年3月齐齐哈尔医学院附属第一医院收治的98例急性脑梗死患者作为研究对象,按照随机数字表法分为对照组48例与观察组50例。对照组采用奥扎格雷钠治疗,观察组另外给予丁苯酞氯化钠注射液治疗,比较两组的治疗效果。结果观察组治疗有效率高于对照组(P<0.05);治疗后,观察组美国国立卫生院卒中量表(NIHSS)评分、白细胞介素-6(IL-6)低于对照组(P<0.05),日常生活能力评定表(ADL)评分、胆碱酯酶(CHE)高于对照组(P<0.05);治疗后,观察组T波异常、ST-T段压低、异常Q波、房性/室性期前收缩、快速性心律失常发生率及QT离散度低于对照组(P<0.05);治疗后,观察组生理功能、生理职能、躯体疼痛、总体健康、社会功能、精力、情感职能、精神健康评分高于对照组(P<0.05)。结论丁苯酞氯化钠联合奥扎格雷钠治疗急性脑梗死效果显著,可有效改善神经功能,提高生命质量。

Objective To explore the clinical effect of butylphthalide sodium chloride combined with ozagrel sodium in the treatment of patients with acute cerebral infarction.Methods 98 patients with acute cerebral infarction admitted to the First Affiliated Hospital of Qiqihar Medical College from March 2018 to March 2020 were selected as the research objects,and were divided into the control group of 48 cases and the observation group of 50 cases according to the random number table method.The control group was treated with sodium ozagrel,and the observation group was treated with sodium butylphthalide and chloride injection.The therapeutic effects of the two groups were compared.Results The effective rate of the observation group was higher than that of the control group(P<0.05);After treatment,the scores of NIHSS and IL-6 in the observation group were lower than those in the control group(P<0.05),while the scores of ADL and CHE in the observation group were higher than those in the control group(P<0.05);After treatment,the incidence of abnormal T wave,ST-T segment depression,abnormal Q wave,atrial/ventricular premature contraction,tachyarrhythmia and QT dispersion in the observation group were lower than those in the control group(P<0.05);After treatment,the scores of physiological function,physiological function,body pain,general health,social function,energy,emotional function and mental health in the observation group were higher than those in the control group(P<0.05).Conclusion Butylphthalide sodium chloride combined with ozagrel sodium has a significant effect in the treatment of acute cerebral infarction,which can effectively improve the neurological function and improve the quality of life.