硫辛酸联合缬沙坦治疗糖尿病肾病的疗效及对氧化应激与炎症反应的影响

Effect of Lipoic Acid Combined with Valsartan on Diabetic Nephropathy and Its Effects on Oxidative Stress and Inflammatory Reaction

目的探讨硫辛酸联合缬沙坦治疗糖尿病肾病的疗效及对氧化应激、炎症反应的影响。方法选取2020年3月至2021年3月江南大学附属医院收治的132例糖尿病肾病患者作为研究对象,采用随机数字表法分为观察组与对照组,各66例。对照组患者给予缬沙坦治疗,观察组在对照组治疗基础上采用硫辛酸治疗,两组患者均治疗两周。比较两组患者临床疗效以及治疗前后氧化应激指标[总抗氧化能力(TAC)、超氧化物歧化酶(SOD)、丙二醛(MDA)]水平和炎症因子[超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]水平,统计两组患者治疗过程中不良反应发生情况。结果观察组患者治疗有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,两组患者TAC、SOD水平明显升高,MDA水平显著下降,且观察组患者TAC、SOD水平明显高于对照组,MDA水平显著低于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者hs-CRP、IL-1β、TNF-α水平明显低于对照组,差异有统计学意义(P<0.05);在治疗过程中两组患者均出现不良反应,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论给予糖尿病肾病患者硫辛酸联合缬沙坦治疗,能够有效提高治疗效果,有助于减轻患者氧化应激反应,对于降低血清炎症因子释放也有着重要作用。

Objective To explore the effect of lipoic acid combined with valsartan on diabetic nephropathy and its effects on oxidative stress and inflammatory reaction.Methods A total of 132 patients with diabetic nephropathy who were treated in Affiliated Hospital of Jiangnan University from March 2020 to March 2021 were randomly divided into the observation group and the control group with 66 cases in each group according to the random number table method.The patients in the control group were treated with valsartan,and the patients in the observation group were treated with lipoic acid on the basis of the treatment in the control group.The patients in both groups were treated for two weeks.The clinical efficacy and the levels of oxidative stress indicators[total antioxidant capacity(TAC),superoxide dismutase(SOD),malondialdehyde(MDA)]and inflammation factors[high-sensitivity C-reactive protein(hs CRP),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)]before and after treatment were compared between the two groups.The adverse reactions of patients in two groups during treatment were counted.Results The effective rate of the observation group was significantly higher than that of the control group(P<0.05);After treatment,the levels of TAC and SOD in the two groups were significantly increased(P<0.05),while the levels of MDA in the observation group were significantly higher than those in the control group(P<0.05),the levels of MDA in the observation group were significantly lower than those in the control group(P<0.05);After treatment,the levels of inflammatory factors in the two groups decreased significantly(P<0.05),and the levels of hs-CRP、IL-1β、TNF-αin the observation group were significantly lower than that in the control group(P<0.05);During the treatment,adverse reactions occurred in both groups,and there was no significant difference between the two groups(P>0.05).Conclusion The treatment of diabetic nephropathy patients with lipoic acid combined with valsartan can effectively improve the treatment effect,help reduce the oxidative stress reaction of patients,and reduce the release of inflammatory factors in serum.