布南色林与舍曲林治疗精神分裂症的疗效及对患者服药依从性及糖脂代谢的影响

The Efficacy of Bunanserin and Sertraline in the Treatment of Schizophrenia and Their Effects on Medication Compliance and Glucose and Lipid Metabolism

目的探讨布南色林与舍曲林治疗精神分裂症的疗效及对患者服药依从性及糖脂代谢的影响。方法选取丹东市第三医院2018年6月至2021年6月收治的60例精神分裂症患者作为研究对象,应用随机数字分组法将其依照1∶1的比例分为观察组与对照组,各30例。对照组应用舍曲林治疗,观察组应用布南色林治疗,比较两组患者阴性与阳性症状量表(PANSS)评分与住院时间,糖脂代谢情况以及服药依从性。结果治疗前,两组患者阳性症状与阴性症状评分比较差异无统计学意义(P>0.05),治疗后评分均降低(P<0.05),且观察组较对照组低(P<0.05),观察组住院时间较对照组短(P<0.05);两组患者治疗前糖化血红蛋白、餐后2 h血糖与空腹血糖水平比较差异无统计学意义(P>0.05),治疗后两组患者糖化血红蛋白、餐后2 h血糖与空腹血糖水平均升高(P<0.05),但观察组低于对照组(P<0.05);两组患者治疗前三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平比较差异无统计学意义(P>0.05),治疗后两组患者HDL水平比较差异无统计学意义(P>0.05),两组患者TG、LDL水平升高,但观察组低于对照组,差异有统计学意义(P<0.05);观察组患者服药依从性明显高于对照组(P<0.05)。结论布南色林与舍曲林能够对精神分裂症起到很好的治疗效果,但布南色林的治疗效果优于曲舍林,能进一步减轻临床症状,缩短住院时间,对糖脂代谢影响较小,能够提升患者治疗依从性。

Objective To explore the efficacy of bunanserin and sertraline in the treatment of schizophrenia and their effects on medication compliance and glucose and lipid metabolism.Methods 60 patients with schizophrenia treated in Dandong Third Hospital from June 2018 to June 2021 were selected as the research object.All patients were randomly divided into observation group and control group according to the ratio of 1:1 by random number grouping method,with 30 cases in each group.The control group was treated with sertraline and the observation group was treated with bunanserin.The scores of negative and positive symptom scale(PANSS),length of hospital stay,medication compliance and glucose and lipid metabolism were compared between the two groups.Results Before treatment,there was no difference in PANSS score between positive and negative symptoms in 2groups(P>0.05),but after treatment,PANSS score decreased,and the observation group was different with control group(P<0.05),and the length of hospital stay in the observation group was different with control group(P<0.05);There was no difference in glycosylated hemoglobin value,2 h postprandial blood glucose and fasting blood glucose between the two groups before treatment(P>0.05).After treatment,the glycosylated hemoglobin value,2 h postprandial blood glucose and fasting blood glucose in the two groups increased on average,and the observation group was different with the control group(P<0.05);There was no difference in the levels of triglyceride(TG),high density lipoprotein(HDL)and low density lipoprotein(LDL)between the two groups before treatment(P>0.05).There was no difference in the levels of HDL between the two groups after treatment.The levels of TG and LDL in the two groups increased,and the observation group was different with control group(P<0.05).Conclusion Bunanserin and sertraline can play a good therapeutic effect on schizophrenia,but the therapeutic effect of bunanserin is better than that of quselin,which can further reduce patients’clinical symptoms,reduce hospital stay,have no adverse effect on patients’medication compliance,and the level of glucose and lipid metabolism is better,which is worthy of clinical reference.