烟雾病与ABO血型的相关性研究

Research on correlation between Moyamoya disease and ABO blood group

目的 探讨烟雾病(Moyamoya disease, MMD)与ABO血型之间的关联性。方法 回顾2020年1月—2021年12月就诊于郑州大学第一附属医院神经外科的406例烟雾病(病例组)和411例非烟雾病患者(对照组)的临床资料,记录其年龄、性别、高血压史、糖尿病史及ABO血型等,进行简单性差异性比较、单因素和多因素logistics回归分析。结果 烟雾病患者中O血型110人(27.1%),A血型129人(31.8%),B血型124人(30.5%),AB血型43人(10.6%);对照组中O血型100人(24.3%),A血型119人(29.0%),B血型152人(37.0%),AB血型40人(9.7%),两组患者ABO血型分布的差异无统计学意义(P>0.05);将血型按照A型与非A型,B型与非B型,AB与非AB型,O型与非O型转换后进行卡方分析,结果仍表明烟雾病组与对照组之间血型分布无差异(均P>0.05)。单因素回归分析:年龄、高血压史与烟雾病的发生有关(P<0.05),性别、糖尿病史、ABO血型与烟雾病的发生无关(均P>0.05)。多因素logistics回归:年龄与烟雾病的发生相关(OR=0.953, 95%CI 0.943~0.964,P<0.001);高血压史与烟雾病的发生相关(OR=2.915, 95%CI 2.071~4.097,P<0.001);性别、糖尿病史与烟雾病的发生不相关(OR=1.013, 95%CI 0.750~1.336,P>0.05)、(OR=1.514, 95%CI 0.952~2.406,P>0.05);A、B、O、AB血型与烟雾病的发生均缺乏相关性(均P>0.05)。结论 ABO血型与烟雾病的发生无相关性。

Objective To explore the relationship between Moyamoya disease and ABO blood group.Methods Totally 406 cases of moyamoya disease(case group) and 411 cases of non-moyamoya disease(control group) admitted to the neurosurgery department of our hospital from January 2020 to December 2021 were reviewed.Their age, gender, history of hypertension, history of diabetes and ABO blood group were recorded, and simplicity difference comparison and univariate and multivariate logistic regression analysis were performed.Results There were 110 patients with O blood type(27.1%), 129 patients with A blood type(31.8%), 124 patients with B blood type(30.5%) and 43 patients with AB blood type(10.6%).In the control group, there were 100 patients with O blood group(24.3%), 119 patients with A blood group(29.0%), 152 patients with B blood group(37.0%), and 40 patients with AB blood group(9.7%).There was no statistical significance in ABO blood group distribution between the two groups(P>0.05).Chi-square analysis was performed after blood group conversion according to type A and non-A, type B and non-B, AB and non-AB, O and non-O, the results still showed no difference in blood group distribution between moyamoya disease group and control group(all P>0.05).Univariate regression analysis showed that age and history of hypertension were related to the occurrence of moyamoya disease(P<0.05), while gender, history of diabetes and ABO blood group were not related to the occurrence of moyamoya disease(P>0.05).Multivariate logistic regression: age was correlated with the occurrence of moyamoya disease(OR=0.953, 95%CI 0.943~0.964, P<0.001).History of hypertension was associated with moyamoya disease(OR=2.915, 95%CI 2.071~4.097, P<0.001).Gender and diabetes history were not correlated with moyamoya disease(OR=1.013, 95%CI 0.750-1.336, P>0.05),(OR=1.514, 95%CI 0.952~2.406, P>0.05);There was no correlation between blood group A、B、O、AB and moyamoya disease(all P>0.05).Conclusion ABO blood group has no correlation with moyamoya disease.