替罗非班及与依达拉奉对房颤合并脑栓塞患者的治疗效果及对神经功能的影响

Therapeutic effects of tirofiban and with edaravone in patients with atrial fibrillation complicated by cerebral embolism and effects on neurological function

目的 分析替罗非班联合依达拉奉对房颤合并脑栓塞患者的治疗效果及对神经功能的影响。方法 选取2021年5月—2022年5月周口市第一人民医院收治疗的90例房颤合并脑栓塞患者为研究对象,并随机分为对照组、研究组,各45例。对照组予以依达拉奉治疗,研究组予以替罗非班联合依达拉奉治疗,对比2组的临床疗效、凝血功能、血液流变学、炎症因子及神经功能。结果 治疗后,研究组的活化部分凝血活酶时间(TT)、凝血酶时间(APTT)、凝血酶原时间(PT)水平高于对照组,全血黏度、血浆黏度、红细胞沉降率、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)水平及美国国立卫生研究所脑卒中评分(NIHSS)低于对照组,差异有统计学意义(P<0.05)。2组的治疗总有效率分别为82.22%、97.78%,差异有统计学意义(P<0.05)。结论 替罗非班联合依达拉奉治疗房颤合并脑栓塞患者的疗效显著,可有效改善患者的凝血功能、血液流变学及神经功能,并减轻炎症反应,临床应用价值较高。

Objective To analyze the therapeutic effect of tirofiban combined with edaravone on patients with atrial fibrillation complicated with cerebral embolism and its influence on neurological function. Methods A total of 90 patients with atrial fibrillation complicated with cerebral embolism treated in our hospital from May 2021 to May 2022 were selected as the research objects and randomly divided into control group and study group, with 45 cases in each group. The control group was treated with edaravone, while the study group was treated with tirofiban combined with edaravone. The clinical efficacy, coagulation function, hemorheology, inflammatory factors and neurological function of the two groups were compared. Results After treatment, the levels of activated partial thromboplastin time(TT), thrombin time(APTT) and prothrombin time(PT) in the study group were higher than those in the control group. The whole blood viscosity, plasma viscosity, erythrocyte sedimentation rate, interleukin-6(IL-6), high-sensitivity C-reactive protein(hs-CRP) levels and National Institute of Health stroke score(NIHSS) were lower than those of the control group, and the differences were statistically significant(P<0.05). The total effective rates of the two groups were 82.22% and 97.78%, respectively, and the difference was statistically significant(P<0.05). Conclusion Tirofiban combined with edaravone is effective in the treatment of patients with atrial fibrillation complicated with cerebral embolism, which can effectively improve the coagulation function, hemorheology and neurological function of patients, and reduce the inflammatory reaction, and has high clinical application value.