基于古籍整理的遗精方药研究

Study on Spermatorrhea Prescription Based on Ancient Books

探究《中华医方》治疗遗精的处方用药规律及特色。从《中华医方》中提取方药信息,手工录入至Excel 2016,建立《中华医方》遗精疾病方药数据库,并对数据进行整理归纳,应用Excel 2016进行频数分析。应用SPSS Modeler 18.0进行关联规则分析及网络化展示,SPSS Statistics 26.0进行系统聚类分析及因子分析。纳入489首方剂,药物328味,用药总频数为4327次,使用频数≥50次的药物有30味,茯苓、龙骨、山药使用频率较高,其中茯苓、龙骨、山药最常用药量分别为10 g、10 g、15 g。四气以温性药为主,五味以甘、苦、辛为主,药物归经主要入肾、肝、心、脾。系统聚类分析将30味高频药物分为8类,C1:芡实、莲须;C2:龙骨、牡蛎;C3:补骨脂、巴戟天;C4:附子、肉桂;C5:韭子、鹿茸、菟丝子;C6:当归、白芍、人参、黄芪、白术、甘草;C7:远志、茯神、酸枣仁、麦冬、生地黄;C8:杜仲、枸杞子、山药、熟地黄、五味子、山茱萸。因子分析得到10个公因子,关联规则分析得到核心药物组合7组。通过对《中华医方》中治疗遗精的方药进行分析,发现治疗遗精多以温性药,甘、辛药,入肾、肝、心经为主,注重采用益肾固精、宁心安神等方法,本研究得出的核心药物组合及聚类分析所得新处方可为遗精的诊疗提供参考依据。

To explore the rules and characteristics of prescriptions used in Zhonghua Yifang for the treatment of spermatorrhea.The prescription information was extracted from Zhonghua Yifang,and manually input into Excel 2016 to establish"Zhonghua Yifang spermatorrhea prescription database".After the data were organized,Excel 2016 was used for frequency analysis.SPSS Modeler 18.0 and SPSS Statistics 26.0 were employed for association rule analysis and network display,and hierarchical cluster analysis and factor analysis,respectively.A total of 489 prescriptions and 328 medicinal materials were included,with the total frequency of medication of 4327 times.There were 30 medicinal materials with frequency of use≥50 times,among which Fuling(茯苓),Longgu(龙骨),and Shanyao(山药)were used more frequently,at the dosage of 10 g,10 g,and 15 g,respectively.Siqi(四气)are mainly Wen(温)medicine,and Wuwei(五味)are Gan(甘),Ku(苦),and Xin(辛).The medicinal materials mainly enter Shenjing(肾经),Ganjing(肝经),Xinjing(心经)and Pijing(脾经).In hierarchical cluster analysis,30 medicinal materials with high frequency of use were divided into 8 categories,that is C1:Qianshi(芡实),Lianxu(莲须);C2:Longgu(龙骨),Muli(牡蛎);C3:Buguzhi(补骨脂),Bajitian(巴戟天);C4:Fuzi(附子),Rougui(肉桂);C5:Jiuzi(韭子),Lurong(鹿茸),Tusizi(菟丝子);C6:Danggui(当归),Baishao(白芍),Renshen(人参),Huangqi(黄芪),Baizhu(白术),Gancao(甘草);C7:Yuanzhi(远志),Fushen(茯神),Suanzaoren(酸枣仁),Maidong(麦冬),Shengdihuang(生地黄);C8:Duzhong(杜仲),Gouqizi(枸杞子),Shanyao(山药),Shudihuang(熟地黄),Wuweizi(五味子),Shanzhuyu(山茱萸).In factor analysis,10 common factors were obtained,and association rule analysis found 7 core drug combinations.Through the analysis of the prescriptions for the treatment of spermatorrhea in Zhonghua Yifang,it is found that the treatment is mainly based on Wen(温)medicine and Gan(甘)and Xin(辛)medicines acting on Shenjing(肾经),Ganjing(肝经),and Xinjing(心经),and focuses on the use of methods such as Yishengujing(益肾固精)and Ningxinanshen(宁心安神).The core drug combinations and new prescriptions obtained in this study provide references for the diagnosis and treatment of spermatorrhea.