清瘟败毒饮加减方治疗儿童疑似流感(毒炽气营证)临床疗效观察

Clinical Efficacy of Modified Qingwen Baidu Yin(清瘟败毒饮加减方) in the Treatment of Children with Suspected Influenza Poisonous Incandescent Qi-Ying Syndrome

目的 探讨清瘟败毒饮加减方治疗儿童疑似流感病例(毒炽气营证)的疗效。方法 将2017年11月—2018年12月在天津中医药大学第一附属医院儿科门/急诊就诊的疑似流感病例患儿分为试验组与对照组,每组各30例。试验组服用中药汤剂清瘟败毒饮加减方,观察组服用奥司他韦颗粒抗病毒治疗,疗程均为5 d。比较两组患儿中医证候疗效、完全退热时间、临床痊愈时间、流感主要症状缓解时间及不良事件发生率。结果 试验组完全退热时间、临床痊愈及咳嗽、咽红肿症状缓解时间均短于对照组(P<0.05);试验组的愈显率和总有效率均高于对照组,两组的愈显率差异具有统计学意义(P<0.05),但总有效率差异无统计学意义(P>0.05)。试验组不良事件发生率为3.45%,对照组不良事件发生率为16.67%,两组差异无统计学意义(P>0.05)。结论 清瘟败毒饮加减方治疗儿童疑似流行性感冒病例(毒炽气营证)临床疗效确切,能够缩短完全退热时间、临床痊愈时间,提高中医证候疗效,改善咳嗽、咽红肿症状。

Objective To observe the clinical efficacy of Modified Qingwen Baidu Yin(清瘟败毒饮加减方)in the treatment of children with suspected influenza cases poisonous incandescent Qi-Ying syndrome.Methods Children with suspected influenza cases who visited the outpatient and emergency department of pediatrics in the first affiliated hospital of Tianjin university of TCM from November 2017 to December 2018were divided into an experimental group and a control group,with 30 cases in each group.The experimental group was treated with Modified Qingwen Baidu Yin,while the observation group was treated with oseltamivir granules,with a course of 5 days.The TCM symptom efficacy,the complete antipyretic time,clinical recovery time,time of disappearance of main symptoms of influenza and the incidence of adverse events were compared between the two groups.Results The time of complete antipyretic,clinical recovery,cough and pharyngeal redness and swelling symptom remission in the experimental group was shorter than that in the control group(P<0.05),and the greater significance and total effective rate of the experimental group were higher than that in the control group.The greater significance of the two groups was statistically significant(P<0.05),but the total effective rate was not statistically significant(P>0.05).The incidence of adverse events was 3.45%in the experimental group and 16.67%in the control group,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Qingwen Baidu Yin has remarkable clinical efficacy in treating children suspected influenza cases poisonous incandescent Qi-Ying syndrome,which can shorten the time of complete antipyretic and clinical recovery,improve the efficacy of TCM syndromes,relieve cough and pharyngeal pain.