复方黄柏液联合白芍总苷胶囊治疗糜烂型口腔扁平苔藓的短期临床疗效观察

Clinical effect of compound phellodendron gargle with total glucosides of paeony capsule in the treatment of erosive oral lichen planus

目的观察复方黄柏液与白芍总苷胶囊联合治疗糜烂型口腔扁平苔藓(oral lichen planus,OLP)的短期应用效果。方法将62位病患采用平行、随机的办法等为对照组和观察组。各组的病患均给予白芍总苷胶囊口服,观察组病患则辅用复方黄柏液口腔含漱。基于疼痛程度(VAS)和体征评估,治疗30 d后就各组病患应用效果予以对比,评价各组的口腔疼痛情况、病损面的愈合情况及治疗有效率的改变,从而评估复方黄柏液联合白芍总苷胶囊治疗糜烂型OLP的短期临床疗效。应用SPSS22.0对各组数据进行统计分析。结果治疗30 d后观察组病患的VAS和体征评分及对照组的VAS评分较治疗前均有明显改善,此外,观察组VAS评分以及治疗有效性都明显高于对照组,P<0.05。结论复方黄柏液和白芍总苷胶囊联合应用可提高糜烂型OLP的治疗效果,切实降低了病患的口腔疼痛情况,且安全性好,具有推广使用价值。

Objective To observe the short-term clinical effect of compound phellodendron gargle combined with the total glucosides of paeony(TGP)in the treatment of erosive oral lichen planus(OLP).Methods 62 patients were divided into observation group and control group through a designed parallel randomized controlled study.All the patients used the total glucosides of paeony capsule,the patients in the observation group also used the compound phellodendron gargle.The pain condition,the healing condition of face,and the treatment effective in both group were evaluated through physical signs and VAS scores evaluations by SPSS 22.0,which could further evaluate the short-term clinical efficacy of compound phellodendron.Results After 30 days,the scores of VAS and physical signs of each group are much better than before.And the scores of VAS and treatment effective of observation group were significantly better than those of the other control groups(P<0.05).Conclusion The application of phellodendron gargle with total glucosides of paeony capsule could improve the treatment effect of OLP patients and reduce the oral pain,which could be used widely in clinical practice.