射麻止喘液联合常规西医治疗寒饮伏肺型慢性阻塞性肺疾病急性加重患者的临床疗效

Clinical Efficacy of She Ma Zhichuan Oral Liquid Combined with Conventional Western Medicine Treatment for the Treatment of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Retention of Cold Fluid in Lung Syndrome

【目的】观察射麻止喘液联合常规西医治疗寒饮伏肺型慢性阻塞性肺疾病急性加重(AECOPD)患者的临床疗效。【方法】将36例寒饮伏肺型AECOPD患者随机分为试验组和对照组,每组各18例。对照组给予常规西医治疗,试验组给予射麻止喘液联合常规西医治疗,疗程均为10 d。观察2组患者治疗前后中医证候积分和6 min步行距离(6MWD)的变化情况,并评价2组患者的临床疗效和安全性。【结果】(1)经治疗10 d后,试验组的总有效率为94.44%(17/18),对照组为83.33%(15/18);组间比较(秩和检验),试验组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的中医证候总积分和各项中医证候积分(包括咳嗽、咯痰、喘息、胸闷、气短、喉中痰鸣和肺部啰音等)均较治疗前明显降低(P<0.05或P<0.01),且试验组对中医证候总积分和咳嗽、咳痰、喉中痰鸣等3项中医证候积分的降低作用均明显优于对照组,差异均有统计学意义(P<0.05或P<0.01)。(3)治疗后,2组患者的6MWD均较治疗前明显提高(P<0.01),且试验组的提高作用明显优于对照组,组间治疗前后差值比较,差异有统计学意义(P<0.05)。(4)治疗期间,2组患者均未发生明显不良反应,且2组患者的血常规及肝肾功能等安全性指标均未见明显异常。【结论】射麻止喘液联合常规西医治疗能更有效地缓解寒饮伏肺型AECOPD患者的临床症状,并提高运动耐力,临床疗效和安全性均较好。

Objective To observe the clinical efficacy of She Ma Zhichuan Oral Liquid combined with conventional western medicine treatment in treating patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with retention of cold fluid in lung syndrome.Methods A total of 36 AECOPD patients with retention of cold fluid in lung syndrome were randomly divided into trial group and control group,with 18 cases in each group.The control group was given conventional western medicine treatment,and the trial group was given She Ma Zhichuan Oral Liquid combined with conventional western medicine treatment.The course of treatment lasted for10 days.The changes of traditional Chinese medicine(TCM)syndrome scores and 6-minute walking distance(6MWD)in the two groups were observed before and after treatment.After treatment,the clinical efficacy and safety of the two groups were also evaluated.Results(1)After 10 days of treatment,the total effective rate of the trial group was 94.44%(17/18)and that of the control group was 83.33%(15/18).The intergroup comparison(by rank sum test)showed that the efficacy of the trial group was significantly superior to that of the control group(P<0.05).(2)After treatment,the total scores of TCM syndrome and the scores of TCM symptoms of cough,expectoration,wheezing,chest distress,shortness of breath,wheezing sound in the throat and lung rales of the two groups were significantly decreased compared with those before treatment(P<0.05 or P<0.01).The trial group was more effective on lowering the total scores of TCM syndrome and the scores of cough,expectoration,and wheezing sound in the throat than the control group,and the differences were statistically significant(P<0.05or P<0.01).(3)After treatment,the 6MWD of the two groups was significantly increased compared with that before treatment(P<0.01).The effect on increasing 6MWD of the trial group was significantly superior to that of the control group,or the difference of the pre-and post-treatment difference of 6MWD between the two groups was statistically significant(P<0.05).(4)During the treatment,there were no obvious adverse reactions occurring in the two groups,or no significant abnormalities were found in the safety indicators of the blood routine test,and liver and kidney function in the two groups.Conclusion She Ma Zhichuan Oral Liquid combined with conventional western medicine treatment has significant effect in treating AECOPD patients with retention of cold fluid in lung syndrome.The combined therapy is effective on relieving the symptoms and improving the exercise tolerance,and has excellent clinical efficacy and high safety profile.