周少虎治疗男性不育少弱精子症用药规律的数据挖掘分析

Data Mining of Medication Rules for Male Infertility of Oligoasthenospermia Treated by ZHOU Shao-Hu

采用频数分析、关联规则分析、聚类分析等方法对周少虎教授治疗男性不育少弱精子症的中药处方进行数据挖掘,分析其组方用药特点。共纳入195首处方,涉及中药60味;其中使用频次≥93次的药物有13味,分别是枸杞子、盐菟丝子、五味子、炙甘草、淫羊藿、黄芪、当归、盐杜仲、土茯苓、酒黄精、覆盆子、丹参、车前子;性味主要以甘平温为主,归经主要归肾、肝、脾经。关联规则分析结果显示,药物组合使用频次最高的是枸杞子-盐菟丝子、枸杞子-盐菟丝子-五味子、枸杞子-盐菟丝子-五味子-炙甘草、枸杞子-盐菟丝子-五味子-炙甘草-淫羊藿。聚类分析结果显示,其高频用药可聚为5类。分析结果提示,周少虎教授基于“辨精论治”的思路治疗少弱精子症,对患者首辨阴阳、再辨气血进行分类施治;以益肾活血、疏肝解郁、清热利湿为治法,多采用补血、活血、疏肝、益肾、填精、清热等药物。

Frequency analysis,association rule analysis,and cluster analysis methods were used to analyze the prescriptions for male infertility of oligoasthenospermia treated by Professor ZHOU Shao-Hu,so as to explore the Chinese medicine medication rules for oligoasthenospermia.A total of 195 prescriptions involving 60 herbs were eventually included.Of the 60 herbs,the 13 herbs with the medication frequency being or over 93 times were Fructus Lycii,salt-processed Semen Cuscutae,Fructus Schisandrae Chinensis,Radix Glycyrrizae Praeparata,Herba Epimedii,Radix Astragali,Radix Angelicae Sinensis,salt-processed Cortex Eucommiae,Rhizoma Smilacis Glabrae,wine-processed Rhizoma Polygonati,Fructus Rubi,Radix Salviae Miltiorrhizae and Semen Plantaginis.Most of the herbs had the nature and flavor of being warm,mild and sweet,and had the meridian tropism of kidney,liver and spleen meridians.The results of association rule analysis showed that the leading4 herbal combinations with high frequency were as follows:(1)Fructus Lycii and salt-processed Semen Cuscutae;(2)Fructus Lycii,salt-processed Semen Cuscutae,and Fructus Schisandrae Chinensis;(3)Fructus Lycii,salt-processed Semen Cuscutae,Fructus Schisandrae Chinensis,and Radix Glycyrrizae Praeparata;(4)Fructus Lycii,salt-processed Semen Cuscutae,Fructus Schisandrae Chinensis,Radix Glycyrrizae Praeparata,and Herba Epimedii.The results of cluster analysis showed that the high-frequency herbs can be classified into five categories.The results suggest that Professor ZHOU Shao-Hu follows the principle of differentiation of sperm for the treatment of oligoasthenospermia.During the treatment,Professor ZHOU Shao-Hu identifies the deficiency of yin and yang firstly,and then differentiates the deficiency of qi and blood.Therapies of tonifying kidney and activating blood,soothing liver and relieving depression,and clearing heat and removing dampness are adopted,and the herbs for nourishing blood,activating blood,soothing liver,tonifying kidney,replenishing essence and clearing heat are frequently used.