甲状腺疾病患者肌酐校正尿碘指标的效果研究

Study on the effect of creatinine correction of urinary iodine index in patients with thyroid disease

目的运用肌酐校正尿碘的方法对唐山地区甲状腺疾病患者尿液标本进行检测,探索尿碘水平及肌酐校正后的尿碘水平与甲状腺疾病间可能存在的关系。方法选取152例正常成人体检者的尿液作为对照组,收集5种甲状腺疾病患者尿样共354例,按病种分为5组。对所有标本进行尿碘和肌酐检测,对各分组所得的尿碘数据和经肌酐校正后的尿碘数据进行统计学分析。结果采用尿碘数据对各甲状腺疾病组与对照组进行多组比较显示,差异有统计学意义(P<0.05)。进一步比较表明,桥本氏甲状腺炎组和甲状腺功能减退组与对照组比较,差异有统计学意义(P<0.05)。采用肌酐校正后的尿碘数据对各甲状腺疾病组与对照组进行多组比较显示,差异没有统计学意义(P>0.05)。结论几种甲状腺疾病的发病可能与碘的摄入水平无关。采用肌酐校正尿碘的方法能够纠正尿量对尿碘结果的干扰。甲状腺疾病患者应根据个体化的尿碘检测来指导碘的摄入。

Objective Urine samples of patients with thyroid diseases in Tangshan area were detected by creatinine correction of urinary iodine,objective to explore the possible relationship between urinary iodine level and thyroid diseases and the possible relationship between creatinine corrected urinary iodine level and thyroid diseases.Methods Urine samples of 152healthy adults were collected as control group,urine samples of 354patients with 5thyroid diseases were collected,they were divided into 5groups according to the disease types.Urinary iodine and creatinine were detected in all samples,the urinary iodine data and creatinine corrected urinary iodine data were statistically analyzed.Results The data of urinary iodine were used to compare the thyroid disease group with the control group,the difference was statistically significant(P<0.05).Further comparison shows that,hashimoto’s thyroiditis group compared with the control group and hypothyroidism group compared with the control group,the difference was statistically significant(P<0.05).The urinary iodine data corrected by creatinine were used to compare the thyroid disease group with the control group,the difference was not statistically significant(P>0.05).Conclusion The incidence of several thyroid diseases may not be related to the level of iodine intake.Using creatinine to correct urinary iodine can correct the interference of urine volume on the results of urinary iodine.Patients with thyroid diseases should be guided by individual urinary iodine test.