ANKK1基因多态性与非典型抗精神病药物诱导的代谢综合征的相关性研究

Relationship between ANKK1 gene polymorphism and atypical antipsychotic drug-induced metabolic syndrome

目的探索ANKK1基因rs1800497位点多态性与非典型抗精神病药物诱导的代谢综合征(MS)的相关性。方法纳入94例精神分裂症患者,采用微量荧光免疫法检测其ANKK1基因rs1800497位点分型,收集患者社会人口学信息、临床特征等数据。采用χ^(2)检验比较患者性别与发生MS的相关性,基因多态性与MS发生及其危险因素的相关性。结果94例患者包括GG型24例(25.53%)、GA型51例(54.26%)、AA型19例(20.21%);其中发生MS的有45例(47.87%),且男性患者的发生率显著高于女性(P<0.05)。ANKK1基因rs1800497位点多态性与发生MS无相关性(P=0.452);但A等位基因与高血糖显著相关(χ^(2)=4.379,P=0.036),与腹型肥胖、高血压、高TG、低HDL-C均无相关性(P>0.05),提示A等位基因是诱发精神分裂症患者高血糖的相对危险因素[OR=2.008,95%CI(1.039,3.881)]。结论ANKK1基因rs1800497位点多态性与非典型抗精神病药物诱发MS无相关性,而携带A等位基因的精神分裂症患者发生高血糖的可能性更高,且男性患者MS发生率显著高于女性。

OBJECTIVE To explore the relationship between the ANKK1 rs1800497 polymorphism and atypical antipsychotic drug-induced metabolic syndrome(MS).METHODS Totally 94 patients with schizophrenia were included,and ANKK1 rs1800497 genotypes of patients were detected by micro-fluorescence immunoassay;social demographic information,clinical characteristics and other data were collected.The χ^(2) test was used to compare the correlation between the sex of patients and the occurrence of MS,and the correlation between gene polymorphism and the occurrence of MS and its risk factors.RESULTS Totally 94 patients included 24 cases(25.53%)of GG,51 cases(54.26%)of GA and 19 cases of AA(20.21%).Among them,there were 45 cases(47.87%)of MS,and the incidence of MS in male was higher than that in female(P<0.05).Genotype analysis showed that ANKK1 rs1800497 polymorphism was not associated with MS(P=0.452).ANKK1 rs1800497 A allele was significantly associated with hyperglycemia(χ^(2)=4.379,P=0.036),while it was not related to abdominal obesity,hypertension,high level of TG and low level of HDL-C(P>0.05),suggesting that for patients with schizophrenia,allele A was a relative risk factor for inducing hyperglycemia[OR=2.008,95%CI(1.039,3.881)].CONCLUSIONS ANKK1 rs1800497 polymorphism has no correlation with the induction of MS by atypical antipsychotics,while the schizophrenia patients with A allele are more likely to induce hyperglycemia.The incidence of MS in male patients is significantly higher than that in female patients.