β-卡巴林类化合物的合成研究进展

Research Progress in Synthesis ofβ-Carboline Compounds

卡巴林类化合物是一种吲哚类生物碱,其结构中含有三环吡啶并吲哚的母核,广泛存在于天然产物中。其类型主要有4种:α-卡巴林、β-卡巴林、γ-卡巴林、δ-卡巴林。其中,β-卡巴林类化合物因其具有广泛的药理活性,如:抗肿瘤、抗阿尔茨海默病等,得到了深入的研究。综述了β-卡巴林类化合物的合成研究进展,为寻找高效、便捷、反应条件温和的β-卡巴林类化合物合成方法提供了参考。

Carboline compounds are a kind of indole alkaloids,which contain the nucleus of tricyclic pyridoindole in the structure,and exist widely in natural products.There are four main types:α-carboline,β-carboline,γ-carboline,andδ-carboline.Among them,β-carboline compounds have been intensively studied because of their extensive biological activities,such as anti-tumor and anti-Alzheimer′s disease.In this paper,we review the research progress in the synthesis ofβ-carboline compounds,which provides a reference for the development of efficient,convenient,and mild synthesis methods ofβ-carboline compounds.