Host–Guest Interaction Driven Peptide Assembly into Photoresponsive Two-Dimensional Nanosheets with Switchable Antibacterial Activity

Selectively controlling the bioactivity of antimicrobial peptides is not only a fascinating scientific challenge but also a necessity in localized antibacterial therapy.Here,a smart antimicrobial system has been fabricated via host–guest driven dynamic selfassembly between a branched cyclodextrin and cationic linear peptides appended with azobenzene side chains.The self-assembly structure of the host–guest system could be controlled reversibly through the photoresponsive isomerization of azobenzene moieties.