肝静脉压力梯度对肝移植受者术前评估及预后预测的价值

Value of hepatic venous pressure gradient in preoperative evaluation and prognosis prediction in liver transplant recipients

肝静脉压力梯度(HVPG)是诊断门静脉高压的“金标准”,可用于肝硬化的评估,与终末期肝病模型(MELD)评分系统联合应用能更精准地匹配肝硬化肝移植供受者,选择合适的手术时机,并为患者在等待肝移植期间的桥接治疗提供指导。除此之外,HVPG也能预测肝移植受者的预后,并为可能出现的并发症提供早发现、早干预的依据。因此,本文通过对HVPG在肝移植受者术前评估及预后预测的价值进行综述,以期为临床肝移植受者术前和术后的诊疗提供指导。

Hepatic venous pressure gradient(HVPG)is the“gold standard”for the diagnosis of portal hypertension,which could be applied in the evaluation of liver cirrhosis.Combined use of HVPG with model for endstage liver disease(MELD)scoring system may more accurately match the donors and recipients undergoing liver transplantation for liver cirrhosis,select the appropriate timing of surgery,and provide guidance for bridging treatment for patients on the waiting list for liver transplantation.Besides,HVPG may also predict clinical prognosis of liver transplant recipients,and provide evidence for early detection and intervention of potential complications.Therefore,the value of HVPG in preoperative evaluation and prognosis prediction of liver transplant recipients was reviewed,aiming to provide guidance for clinical diagnosis and treatment of liver transplant recipients before and after surgery.