皮肤鳞状细胞癌的肿瘤干细胞研究进展

Research progress in biotherapy of cutaneous squamous cell carcinoma

皮肤鳞状细胞癌(cSCC)属最常见的皮肤恶性肿瘤之一,常在癌前病变光线性角化病的基础上发生。cSCC起源于表皮或毛囊附属器角质形成细胞。肿瘤干细胞存在于cSCC中,它与正常表皮干细胞有一定的相似性。但它启动cSCC的形成,并与转移和治疗抵抗有关。因此,了解cSCC中肿瘤干细胞生物学特征并区分其与正常表皮干细胞的差别,有助于开发治疗cSCC的新靶向治疗药物,尤其是针对预后不良的cSCC。本文综述了cSCC中肿瘤干细胞的起源、特性和其标记物的研究进展。

Cutaneous squamous cell carcinoma(cSCC)is one of the most common skin malignancies, which often occurs on the basis of actinic keratosis. cSCC originates from keratinocytes of epidermis or hair follicle appendage.. Cancer stem cells are found in cSCC,which have certain similarities with normal epidermal stem cells. But it initiates cSCC formation and is associated with metastasis and therapy resistance. Therefore,understanding the biological characteristics of cancer stem cells in cSCC and distinguishing them from normal epidermal stem cells will help to develop new-targeted biomarkers for cSCC,especially for cSCC with poor prognosis. This article reviews the research progress on the origin,characteristics and biomarkers of cancer stem cells in cSCC.