miR-326的功能及其在自身免疫病中作用的研究进展

Research progress on function of miR-326 and its role in autoimmune diseases

自身免疫病(AD)是由免疫系统对自身抗原失耐受引起,并进一步诱发组织损伤和炎症的一类疾病。miRNA通过与靶基因3’端非编码区特异性结合阻止蛋白质翻译或引起mRNA降解,从而在转录后水平调控基因表达,参与多种免疫细胞的生长发育和机体的免疫调节,因此miRNA可能成为AD的潜在治疗靶点。miR-326作为miRNA大家族中的研究热点之一,在AD中发挥重要作用,但其在AD中的研究尚存在许多不足之处,积极探索miR-326在AD中的作用对阐明AD的病理过程及开拓AD治疗新策略具有重要意义。

Autoimmune disease(AD)is a type of disease that caused by intolerance of autoantigens and further induces tissue damage and inflammation.miRNA specifically binds to 3’non-coding region of the target gene to prevent protein translation or cause mRNA degradation,thereby regulating gene expression at post-transcriptional level,participating in growth and development of a variety of immune cells and body’s immune regulation functions,so miRNA may become a potential therapeutic target for AD.As one of the research hotspots in miRNA family,miR-326 is considered to play an important role in AD,while has many shortcomings.Actively explore the role of miR-326 in AD to clarify pathological process of AD and open up new strategy of AD treatment is of great significance.