摘要
Protein cages have promising applications in highly efficient gene transportation.Many methods of engineering protein–interface interactions have been developed to build such viral mimics.Missing in current approaches is how to turn off the interactions and unpack the protein shell for controlled cargo delivery.Here,we present a concise protein allosteric strategy to create protein nanocages with dismountable coats.
基金
support of the National Natural Science Foundation of China(nos.21674022 and 51703034)
the National Defense Science and Technology Innovation Zone(163 Program)
the Shanghai Rising-Star Program(no.19QA1400700).
