摘要
The accumulation of solubleβ-amyloid aggregates(sAβs)is one of the main culprits in Alzheimer’s disease(AD)progression,which can lead to synaptic dysfunction and subsequent neurodegeneration.Herein,we describe a nanoscavenger with novel structure that can cross the blood–brain barrier(BBB),accurately collect neurotoxic sAβs,and facilitate amounts ofβ-amyloid(Aβ)clearance.
基金
supported by the National Key Research and Development Programs of China(grant no.2018YFA0209700)
the National Natural Science Foundation of China(NSFC
grant nos.51673100 and 21620102005)
the Fundamental Research Funds for the Central Universities(Nankai University
grant nos.ZB19100123 and ZB16008705)
the Tianjin Natural Science Foundation(grant no.18JCQNJC03600)
the China Postdoctoral Science Foundation(grant no.2019M660975).
