从经典源流探析脓毒症热毒论治

Analysis on the treatment of sepsis from the classical heat toxin of traditional Chinese medicine

脓毒症是一种临床常见的感染失控紊乱引发的急危重感染性疾病,热毒是贯穿其整个疾病过程的重要致病因素。文章通过溯源经典古籍,总结了热毒病邪的特性,并结合脓毒症的疾病特点和临床表现,探讨热毒病邪与脓毒症的关系,在清热解毒治疗理念下,归纳挖掘清热解毒类中药治疗脓毒症的信号通路和靶点,阐述中药在脓毒症治疗中的应用优势,以期拓宽中医经典及中医药在脓毒症领域的应用。

Sepsis is an acute and critical infectious diseases caused by uncontrolled infection disorder, which is a common clinical disease. Hot toxin is an important pathogenic factor throughout the whole disease process. Through tracing the source of classic ancient books, the article summarized the characteristics of heat toxin pathogen, and combined with the disease characteristics and clinical manifestations of sepsis, discussed the relationship between heat toxin pathogen and sepsis. Under the concept of heat clearing and detoxification treatment, the article summarized and excavated the signal pathways and targets of heat clearing and detoxification traditional Chinese medicine in the treatment of sepsis, and expounded the application advantages of traditional Chinese medicine in the treatment of sepsis, with a view to expanding the application of traditional Chinese medicine classics and traditional Chinese medicine in the field of sepsis.