舒芬太尼复合咪达唑仑在支气管镜检查中的应用价值

Application Value of Sufentanil Combined with Midazolam in Bronchoscopy

目的 研究咪达唑仑联合舒芬太尼在无痛清醒镇静支气管镜检查中的应用效果。方法 选取2019年1月-2021年6月在我院进行无痛清醒镇静支气管镜检查的198例患者为研究对象,采用随机数字表法分为对照组和观察组,各99例。对照组采用局部麻醉,观察组在对照组基础上采用咪达唑仑联合舒芬太尼,比较两组不良反应发生率、不同时间段心率(HR)、血氧饱和度(SpO_(2))、收缩压(SBP)、舒张压(DBP)、镇静评分、检查满意度评分及愿意再次接受检查率。结果 观察组不良反应发生率为5.05%,低于对照组的11.11%(P<0.05);过声门后即刻,两组HR、SpO_(2)、SBP、DBP均低于入镜前,但观察组高于对照组(P<0.05);观察组镇静评分、检查满意度评分均高于对照组(P<0.05);观察组愿意再次接受检查率为95.96%,高于对照组的76.77%(P<0.05)。结论 咪达唑仑联合舒芬太尼可促进无痛清醒镇静支气管镜检查的顺利进行,该方案对患者生命体征的影响小,可提高其镇静评分和检查满意度评分,使患者更容易接受再次检查,且不良反应少。

Objective To study the application effect of midazolam combined with sufentanil in painless conscious sedation bronchoscopy. Methods A total of 198 patients who underwent painless conscious sedation bronchoscopy in our hospital from January 2019 to June 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 99 cases in each group. The control group was treated with local anesthesia, and the observation group was treated with midazolam combined with sufentanil on the basis of the control group. The incidence of adverse reactions, heart rate(HR), blood oxygen saturation(SpO_(2)), systolic blood pressure(SBP), diastolic blood pressure(DBP), sedation score, examination satisfaction score and willingness to re-examine rate were compared between the two groups. Results The incidence of adverse reactions in the observation group was 5.05%, which was lower than 11.11% in the control group( P<0.05). HR, SpO_(2), SBP and DBP in the two groups at immediately after the glottis were lower than those before entering the endoscope, but those in the observation group were higher than those in the control group(P<0.05). The sedation score and examination satisfaction score of the observation group were higher than those of the control group(P <0.05). The rate of willingness to re-examine in the observation group was 95.96%, which was higher than 76.77% in the control group(P <0.05).Conclusion Midazolam combined with sufentanil can promote the smooth progress of painless conscious sedation bronchoscopy. This scheme has little effect on the vital signs of patients, and can improve their sedation score and examination satisfaction score,make patients more likely to accept reexamination, with fewer adverse reactions.