慢性血栓栓塞性肺动脉高压基础与转化研究进展

Progress in translational research on chronic thromboembolic pulmonary hypertension

慢性血栓栓塞性肺动脉高压(CTEPH)属于肺动脉高压的第四大类,以肺动脉血栓机化、肺血管重塑致血管狭窄或闭塞,肺动脉压力进行性升高,最终出现右心功能衰竭导致患者死亡。CTEPH发病机制有待进一步阐明。然而,对于CTEPH的诊断以及治疗方案尚需要探索,其预后及其机制尚未明确。本文对CTEPH病理机制及基础转化研究新进展进行梳理。

Chronic thromboembolic pulmonary hypertension(CTEPH),the fourth category of pulmonary hypertension,is characterized by pulmonary arterial thrombosis,pulmonary vascular remodeling which leads to vascular stenosis or occlusion,progressive increase in pulmonary arterial pressure,and eventually right heart failure.The pathogenesis of CTEPH remains to be further elucidated.The prognosis and mechanism of CTEPH are unclear.The diagnosis and treatment of CTEPH remains to be further explored.Here,the pathological mechanism and new progress in basic translational research of CTEPH are sorted out in the paper.