滑膜炎颗粒治疗膝关节创伤性滑膜炎的疗效与安全性评价

Efficacy and Safety of Synovitis Granules in Treatment of Knee Traumatic Synovitis

目的:评价滑膜炎颗粒治疗膝关节创伤性滑膜炎的有效性与安全性。方法:选择确诊的膝关节创伤性滑膜炎病例,开水冲服滑膜炎颗粒1袋/次,3次/天,疗程6周。收集治疗前后患者的影像学特征、实验室检查指标、临床症状、疗效和安全性等信息。采用SPSS 22.0软件统计分析。结果:123例膝关节创伤性滑膜炎患者接受了治疗,102例收集到了随访数据。其中,痊愈23例(22.55%),显效67例(65.69%),有效12例(11.76%)。无论是疗程<4周或≥4周,与治疗前相比,治疗后关节疼痛和关节僵硬均明显减轻,关节运动功能得到了明显的改善,且差异具有统计学意义(P<0.05)。试验中未报告相关不良反应。结论:滑膜炎颗粒治疗膝关节创伤性滑膜炎疗效显著,为临床应用提供了证据。

Objective:To evaluate the efficacy and safety of synovitis granules in treatment of knee traumatic synovitis. Methods:The patients whom diagnosed as knee traumatic synovitis were treated with synovitis granules in boiling water 1 sachet/time, 3 times/day for 6 weeks. Patients’ information about imaging features, laboratory test indexes, clinical symptoms, efficacy and safety before and after treatment were collected. SPSS 22.0 software was used for statistical analysis. Results: One hundred and twenty-three patients with knee traumatic synovitis were treated, and follow-up data were collected in 102 patients. Among them, 23 patients(22.55%) were cured, 67 patients(65.69%) were effective, and 12 patients(11.76%) were effective. Whether the duration of treatment was less than or greater than 4 weeks, joint pain and joint stiffness were significantly reduced and joint motion function was significantly improved after treatment compared with that before treatment, and the difference was statistically significant(P<0.05). No related adverse effects were reported in the trial. Conclusion:The efficacy of synovitis granules in the treatment of traumatic synovitis of the knee traumatic synovitis is significant and provides evidence for clinical application. In order to further evaluate its efficacy, a larger clinical trial is recommended.