氮卓斯汀鼻喷剂结合地氯雷他定治疗过敏性鼻炎疗效及药学分析

Azelastine nasal spray combined with desloratadine in the treatment of allergic rhinitis and its pharmacological analysis

目的探讨过敏性鼻炎患者治疗中氮卓斯汀鼻喷剂与地氯雷他定合用的临床价值及药学分析。方法遴选2019年6月-2020年6月80例过敏性鼻炎患者,根据“系统抽样法”分2组—对照组、观察组(n=40);对照组实施氮卓斯汀鼻喷剂治疗,观察组在对照组基础上+地氯雷他定治疗;对比两组治疗结果:临床总疗效、症状积分、炎症因子水平。结果较对照组研究结果,观察组患者治疗总有效率明显更高(95.00%vs77.50%),同时观察组鼻塞、鼻痒、打喷嚏、流鼻涕症状积分均更低(P<0.05);同时两组治疗前炎症因子水平比较(P>0.05),观察组治疗后较对照组IL-4、IL-6、IL-10水平均更低(P<0.05)。结论氮卓斯汀鼻喷剂与地氯雷他定合用治疗过敏性鼻炎患者,不仅有利于患者临床症状的改善,同时可减轻炎症反应,从而实现良好的预后效果。

Objective To investigate the clinical value and pharmacological analysis of azelastine nasal spray combined with desloratadine in the treatment of patients with allergic rhinitis.Methods From June 2019 to June 2020,80 patients with allergic rhinitis were selected.According to the“systematic sampling method”,they were divided into 2 groups—control group and observation group;the control group was treated with azelastine nasal spray,and the observation group was in Control group basic+desloratadine treatment;compare the two treatment results:total clinical efficacy,symptom score,inflammatory factor level.Results Compared with the results of the control group,the total effective rate of treatment for patients in the observation group was significantly higher(95.00%vs 77.50%),while the scores of symptoms of nasal congestion,nasal itching,sneezing,and runny nose were lower in the observation group(P<0.05)At the same time,the levels of inflammatory factors were compared between the two groups before treatment(P>0.05).The levels of IL-4,IL-6 and IL-10 in the observation group after treatment were lower than those in the control group(P<0.05).Conclusion The combination of azelastine nasal spray and desloratadine in the treatment of patients with allergic rhinitis is not only beneficial to the improvement of the clinical symptoms of the patients,but also can reduce the inflammatory response,so as to achieve a good prognostic effect.