胃肠间质瘤复发风险评估研究进展

Advances in recurrence risk assessment of gastrointestinal stromal tumor

鉴定和精准评估胃肠间质瘤(GIST)患者预后相关因素及风险分层,不仅对建立可靠的预后模型和制定完善的随访计划至关重要,而且对选择潜在的新辅助治疗获益人群具有重要意义。尽管目前国际上已建立了多个风险分层模型,但是精准评估患者复发风险仍具有挑战性,且这些预测模型的性能仍需提高。本文综述了GIST患者复发风险评估相关的最新研究进展,总结了肿瘤相关特征参数、新型的实验室检查指标、影像学征象及分子病理学特征相关的潜在的复发风险预测标志物及模型,以期为GIST患者的精准风险分层和个体化靶向治疗评估提供参考。

Identification of prognosis-related risk factors and accurate assessment of risk stratification in patients with gastrointestinal stromal tumor(GIST)is of great significance not only for establishing a reliable prognostic model and developing a follow-up plan but also for selecting potential populations benefiting from neoadjuvant therapies.Although several risk stratification models have been established,it is still challenging to accurately assess patients'risk of recurrence,and the performance of these prediction models still needs to be improved.This review focused on the latest studies in recurrence risk assessment for GIST patients,and summarized potential predictive markers and recurrence risk models related to tumor-related characteristic parameters,novel laboratory examinations,radiological imaging signatures and molecular pathological features,which could provide a reference for accurate risk stratification and individualized targeted therapies for GIST patients.