基于“肺合大肠”理论探讨肠道微生态、黏膜免疫与支气管哮喘之间的相关性

Correlation between intestinal microecology,mucosal immunity and bronchial asthma based on the theory of‘lung being connected with large intestine’in traditional Chinese medicine

支气管哮喘是一种气道慢性炎症性疾病。随着其发病率的逐年增加,学界对其防治愈加重视。目前,随着分子生物学研究的进一步深入,肠道微生态在肺部疾病发生发展过程中所扮演的角色日益被关注,且肺-肠黏膜免疫功能间相关性的研究俨然成为学界的研究热点。而中医自古即有“肺合大肠”的经典之论,故文章基于“肺合大肠”理论探讨肠道微生态、黏膜免疫与支气管哮喘之间的关系,以期为中医药运用肺肠同治法防治支气管哮喘提供新思路及理论依据。

Bronchial asthma is a chronic inflammatory disease of the respiratory tract.With the increase of its incidence,more and more attention has been paid to its prevention and treatment.At present,with the further development of molecular biology research,the role of intestinal microecology in the occurrence and development of lung diseases has attracted increasing attention,and the research on the correlation between lung and intestinal mucosal immune function has become a hot topic in the academic field.Since ancient times,there has been a classical theory of‘lung being connected with large intestine’in Chinese medicine.Therefore,based on the theory of‘lung being connected with large intestine’in Chinese medicine,this paper will explore the relationship between intestinal microecology,mucosal immunity and bronchial asthma,in order to provide new ideas and theoretical basis for the application of combined therapy of lung and intestine in the prevention and treatment of bronchial asthma in Chinese medicine.