轻度认知功能障碍肝气郁结证患者空间和言语工作记忆的事件相关电位特征

Characteristics of ERP on spatial and verbal working memory in patients of mild cognitive impairment with liver qi stagnation syndrome

目的:探讨轻度认知功能障碍(MCI)肝气郁结证患者空间和言语工作记忆的事件相关电位(ERP)特征。方法:采用问卷调查法筛选45~65岁MCI肝气郁结证患者(病例组)和正常中老年人(对照组),各14例,并按年龄(±2.5岁)、性别和受教育年限进行1∶1匹配。以数字为刺激材料制定中文版数字广度n-back实验范式,采用ERP技术检测两组被试空间和言语工作记忆并进行分析。结果:两组被试空间工作记忆均低于言语工作记忆的正确率(P<0.01);两组被试空间和言语工作记忆任务下P2潜伏期均延长(P<0.05);与对照组比较,病例组空间和言语工作记忆任务下P3潜伏期均缩短(P<0.05),且空间工作记忆任务下P3波幅降低(P<0.05)。结论:空间和言语工作记忆P3潜伏期、空间工作记忆P3波幅的改变是MCI肝气郁结证患者的ERP特征。

Objective:To explore the characteristics of event related potentials(ERP)on spatial and verbal working memory in patients of mild cognitive impairment(MCI)with liver qi stagnation syndrome.Methods:Some questionnaires were used to screen 45 to 65-year-old 14 patients of MCI with liver qi stagnation syndrome(case group)and 14 normal people(normal group).The two groups were matched accordingly to the same age(±2.5 years old),the same gender and the same years of education.A Chinese version digit span n-back experimental paradigm was established with numbers as stimulus.The spatial and verbal working memory were evaluated by using event-related potentials to compare the differences of the two groups.Results:The accuracy of spatial working memory in both groups was lower than that of verbal working memory(P<0.01).The latency of P2 under spatial and verbal working memory tasks was prolonged in both groups(P<0.05).Compared with the control group,the case group had shorter P3 latency under spatial and verbal working memory tasks(P<0.05),and lower P3 amplitude under spatial working memory tasks(P<0.05).Conclusion:The P3 latency of both spatial and verbal working memory,and the P3 amplitude of spatial working memory changes are the characteristics of ERP in patients of MCI with liver qi stagnation syndrome.